Research Projects

On the ground of our interests for molecular piracy exerted by tumor cells to survive, adapt and remodel their environment, we explore the signaling mechanisms involved in non-oncogene addiction and loss of vascular homeostasis.
Our research program is organized around four main axis:
1. Vascular Permeability in Tumors.
2. NF-kB-activating Signalosomes in Lymphocytes and Lymphoma.
3. Tumor Vascular Niche in Brain Tumors.
4. Multiprotein Complexes and Dynamics in Lymphocytes.

Please visit our website:  http://nbidere.wixsite.com/soap
Follow us on Twitter: @LabSoap
Follow us on Facebook: Lab Bidere-Gavard

Staff

Julie Gavard, Team Leader
Nicolas Bidère, Researcher, Project Leader
Kilian Trillet, Staff Engineer
Gwennan André-Grégoire, post-doc
An Thys, post-doc
Caroline Nicolau, post-doc
Tiphaine Douanne, PhD student
Kathryn Jacobs, PhD student
Cyndie Ballu, M2
Audrey Gayraud, M2
Andrea Bello, M1

Main Publications

André-Grégoire G, Bidère N, Gavard J. Temozolomide Affects Extracellular Vesicles Released by Glioblastoma Cells. Biochimie (2018)
Jacobs KA, Gavard J. 3D endothelial migration. Methods Mol Biol (2018)
Harford-Wright E, Gavard J. Apelin, the Devil Inside Brain Tumors. J Exp Neurosci (2018)
Harford-Wright, Andre-Gregoire G, Jacobs KA, Treps L, Le Gonidec S, Leclair HM, Gonzalez-Diest S, Roux Q, Guillonneau F, Loussouarn D, Oliver F, Vallette FM, Foufelle F, Valet P, Davenport AP, Glen RC, Bidere N, Gavard J. Pharmacological targeting of apelin impairs glioblastoma growth. Brain (2017)
Treps L, Perret R, Edmond S, Ricard D, Gavard J. Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles. J Extracell Ves (2017)
Jacobs KA, Harford-Wright E, Gavard J. Neutralizing gp130 interferes with endothelial-mediated effects on glioblastoma stem-like cells. Cell Death Diff (2017)
Harford-Wright E, Bidere N, Gavard J. β-escin selectively targets glioblastoma-initiating cell identity to reduce cell viability. Oncotarget (2016)
Douanne T, Gavard J, Bidère N. The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling. J Cell Sci (2016)
Dubois SM, Alexia C, Wu Y, Leclair HM, Leveau C, Schol E, Fest T, Tarte K, Chen Z, Gavard J, Bidere N. A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells. Blood (2014)
Azzi S, Smith SS, Dwyer J, Leclair HM, Alexia C, Hebda JK, Dupin N, Bidere N, Gavard J. YGLF motif in the Kaposi Sarcoma Herpes Virus G protein coupled receptor adjusts NF-κB activation and paracrine actions. Oncogene (2014)
Alexia C, Poalas K, Carvalho G, Zermili N, Dwyer J, Dubois SM, Hatchi EM, Cordeiro N, Smith SS, Castanier C, Le Guelte A, Wan L, Kang Y, Vazquez A, Gavard J, Arnoult D, Bidere N. The endoplasmic reticulum acts as a platform for ubiquitylated components of Nuclear Factor-κB signaling. Sci Signal (2013)
Le Guelte A, Galan-Moya EM, Dwyer J, Treps L, Kettler G, Hebda JK, Dubois S, Auffray C, Chneiweiss H, Bidere N, Gavard J. Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation. J Cell Sci (2012)
Galan-Moya EM, Le Guelte A, Lima Fernandes E, Thirant C, Dwyer J, Bidere N, Couraud PO, Scott MG, Junier MP, Chneiweiss H, Gavard J. Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Rep (2011)

Main Fundings

Fondation ARC pour la Recherche contre le Cancer
Ligue Nationale contre le Cancer
Nantes Métropole
Région Pays-de-la-Loire

Equipe 15

Contact

  • Julie Gavard
  • Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
  • Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1
  • +33 2 28 08 03 27
  • julie.gavard@inserm.fr