Publications Equipe 11

2020 2019 2018 2017

Josephine Briand, Aurelien A Serandour, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Dominique Heymann, Benjamin Ory, Francois M. Vallette, and Pierre-Francois Cartron. N6-Adenosine Methylation of miRNA-200b-3p In uences Its Functionality and Is a Theranostic Tool. Molecular Therapy – Nucleic Acids, 2020. hal-03004313.

Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denie, Catherine Guerin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stephane Minvielle, and Aurelien Serandour. DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clinical Epigenetics, 2020. inserm-03006751.

Sophie Vantyghem, Pierre Peterlin, Sylvain Thepot, Audrey Menard, Viviane Dubruille, Camille De-bord, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Soraya Wuilleme, Catherine Godon, Olivier Theisen, Marion Eveillard, Jacques Delaunay, Herv Maisonneuve, Nadine Morineau, Bruno Villemagne, Stephane Vigouroux, Francois Subiger, Elsa Lestang, Marion Loirat, Anne Parcelier, Pascal Godmer, Melanie Mercier, Adrien Trebouet, Damien Luque Paz, Ronan Le Calloch, Lenaïg Le Clech, Celine Bossard, Anne Moreau, Valerie Ugo, Mathilde Hunault, Philippe Moreau, Steven Le Gouill, Patrice Chevallier, Marie C Bene, and Yannick Le Bris. Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica, 2020. inserm-02552097.

Caroline Rousseau, David M Goldenberg, Mathilde Colombie, Jean-Charles Sebille, Philippe Meingan, Ludovic Ferrer, Pierre Baumgartner, Evelyne M Cerato, Damien Masson, Mario Campone, Aurore Rauscher, Vincent Fleury, Catherine Labbe, Alain Faivre-Chauvet, Jean-Sebastien Fresnel, Claire Toquet, Jacques Barbet, Robert M Sharkey, Loïc Campion, and Francoise Kraeber-Boder. Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer. Journal of Nuclear Medicine, 2020. inserm-02512957.

Tiphaine Delaunay, Carole Achard, Nicolas Boisgerault, Marion Grard, Tacien Petithomme, Camille Chatelain, Soizic Dutoit, Christophe Blanquart, Pierre-Joseph Royer, Stephane Minvielle, Lisa Quetel, Clement Meiller, Didier Jean, Delphine Fradin, Jaafar Bennouna, Antoine Magnan, Laurent Cellerin, Frederic Tangy, Marc Gregoire, and Jean-Francois Fonteneau. Frequent Homozygous Dele-tions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus. Journal of Thoracic Oncology, 2020. inserm-02447160.

Baptiste Le Calvez, Yannick Le Bris, Guillaume Herbreteau, Bastien Jamet, Celine Bossard, Benoit Tessoulin, Thomas Gastinne, Beatrice Mahe, Viviane Dubruille, Nicolas Blin, Chloe Antier, Olivier Theisen, Francoise Kraeber-Bodere, Steven Le Gouill, Marie C. Bene, Philippe Moreau, and Cyrille Touzeau. RASmutation leading to acquired resistance to dabrafenib and trametinib therapy in a multiplemyeloma patient harboring BRAF mutation. European Journal of Haematology, 2020. inserm-02874002.

Maelle Le Thiec, Aude Testard, Ludovic Ferrer, Camille Guillerminet, Olivier Morel, Bruno Maucherat, Daniela Rusu, Sylvie Girault, Marie Lacombe, Hadji Hamidou, Veronique Guerin Meyer, Emmanuel Rio, Sandrine Hiret, Francoise Kraeber-Bodere, Loïc Campion, and Caroline Rousseau. Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer. Cancers, 2020. inserm-02908736.

Jill Corre, Aurore Perrot, Denis Caillot, Karim Belhadj, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, Thierry Facon, Laure Buisson, Laura Do Souto, Romain Lannes, Stephanie Dufrechou, Nais Prade, Frederique Orsini-Piocelle, Laurent Voillat, Arnaud Jaccard, Lionel Karlin, Margaret Macro, Sabine Brechignac, Mamoun Dib, Laurence Sanhes, Jean Fontan, Lauriane Filliatre-Clement, Jean Pierre Marolleau, Stephane Minvielle, Philippe Moreau, and Hervé Avet-Loiseau. Del17p without TP53 mutation confers poor prognosis in intensively treated newly diagnosed multiple myeloma patients. Blood, 2020. inserm-03010010.

Samur Mehmet Kemal, Anil Aktas Samur, Mariateresa Fulciniti, Raphael Szalat, Tessa Han, Ma-sood Shammas, Paul Richardson, Florence Magrangeas, Stephane Minvielle, Jill Corre, Philippe Moreau, Anjan Thakurta, Kenneth C. Anderson, Giovanni Parmigiani, Herve Avet-Loiseau, and Nikhil Munshi. Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Out-come Group. Journal of Clinical Oncology, 2020. inserm-02913784.

Carolane Seiller, Sophie Maiga, Cyrille Touzeau, Celine Bellanger, Charlotte Kervoelen, Geraldine Descamps, Laurent Maillet, Philippe Moreau, Catherine Pellat-Deceunynck, Patricia Gomez-Bougie, and Martine Amiot. Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/ BAK hetero-complexes. Cell Death and Disease, 2020. inserm-02563554.

Anne-Victoire Michaud-Robert, Bastien Jamet, Clement Bailly, Thomas Carlier, Philippe Moreau, Cyrille Touzeau, Mickael Bourgeois, Francoise Kraeber-Bodere, and Caroline Bodet-Milin. FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients? Cancers, 2020. inserm-02908787.

Yannick Le Bris, Florence Magrangeas, Anne Moreau, David Chiron, Catherine Guerin-Charbonnel, Olivier Theisen, Olivier Pichon, Danielle Canioni, Barbara Burroni, Hervé Maisonneuve, Catherine Thieblemont, Lucie Oberic, Emmanuel Gyan, Catherine Pellat-Deceunynck, Olivier Hermine, Marie-Helene Delfau-Larue, Benoit Tessoulin, Marie C Bene, Stephane Minvielle, and Steven Le Gouill. Whole genome copy number analysis in search of new prognostic biomarkers in rst line treatment of mantle cell lymphoma. A study by the LYSA group. Hematological Oncology, 2020. inserm-02874026.

Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen, and Nathalie Labarriere. Increased antitumor e cacy of PD-1- de cient melanoma-speci c human lymphocytes. Journal for Immunotherapy of Cancer, 2020. inserm-02481085.

Basile Henriot, Emmanuel Rouger, Chloé Rousseau, Martine Escoffre, Martine Sébillot, Claude Bendavid, Stephane Minvielle, Hervé Avet-Loiseau, Olivier Decaux, Caroline Moreau. Prognostic value of involved/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients. Clinical Chemistry and Laboratory Medicine. (2019). hal-02120882

Ludivine Morvan, Thomas Carlier, Bastien Jamet, Clément Bailly, Caroline Bodet-Milin, Philippe Moreau, Francoise Kraeber-Bodere, Diana Mateus. Leveraging RSF and PET images for prognosis of Multiple Myeloma at diagnosis. International Journal of Computer Assisted Radiology and Surgery. (2019). hal-02172435

Ludivine Morvan, Diana Mateus, Clément Bailly, Bastien Jamet, Caroline Bodet-Milin, Philippe Moreau, Cyrille Touzeau, Françoise Kraeber-Bodéré, Thomas Carlier. Prédiction de la progression chez des patients atteints de myélome multiple par « Random Survival Forest ».[Poster] SFMN. (2019). hal-02175296

Bastien Jamet, Clément Bailly, Thomas Carlier, Lucie Planche, Cyrille Touzeau, Françoise Kraeber-Bodéré, Philippe Moreau, Caroline Bodet-Milin. Added prognostic value of FDG-PET/CT in relapsing multiple myeloma patients. Leukemia & lymphoma. (2019) 222-225. inserm-01823037

Matthieu Barbaud, Mathieu Frindel, Ludovic Ferrer, Maëlle Le Thiec, Daniela Rusu, Aurore Rauscher, Bruno Maucherat, Pierre Baumgartner, Vincent Fleury, Mathilde Colombié, Agnes Thierry‐Morel, Françoise Kraeber‐Bodéré, Loïc Campion, Caroline Rousseau. 68Ga‐PSMA‐11 PET‐CT study in prostate cancer patients with biochemical recurrence and non‐contributive 18F‐Choline PET‐CT: Impact on therapeutic decision‐making and biomarker changes. Prostate. (2019) 454-461. inserm-01980821

Louise Bouard, Caroline Bodet-Milin, Clément Bailly, Thierry Guillaume, Pierre Peterlin, Alice Garnier, Amandine Bourgeois, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Antoine Bonnet, Marie Bene, Steven Gouill, Philippe Moreau, Françoise Kraeber-Bodéré, Patrice Chevallier. Deauville Scores 4 or 5 Assessed by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Early Post-Allotransplant Is Highly Predictive of Relapse in Lymphoma Patients. Biology of Blood and Marrow Transplantation. (2019) 906-911. inserm-01981440

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-Christine Béné, Patrice Chevallier. FLT3 ligand plasma levels in acute myeloid leukemia. Haematologica. (2019) Epub ahead of print. inserm-01993986

Antonin Papin, Benoit Tessoulin, Céline Bellanger, Anne Moreau, Yannick Le Bris, Hervé Maisonneuve, Philippe Moreau, Cyrille Touzeau, Martine Amiot, Catherine Pellat-Deceunynck, Steven Le Gouill, David Chiron. CSF1R and BTK inhibitions as novel strategies to disrupt the dialogue between mantle cell lymphoma and macrophages. Leukemia. (2019) Epub ahead of print. inserm-02081007

Clément Bailly, Thomas Carlier, Bastien Jamet, Cyrille Touzeau, Philippe Moreau, Françoise Kraeber-Bodéré, Caroline Bodet-Milin. 18F-FDG PET/CT in multiple myeloma: critical insights and future directions. European Journal of Nuclear Medicine and Molecular Imaging. (2019) 1048-1050. inserm-02100540

Pascal Jézéquel, Olivier Kerdraon, Hubert Hondermarck, Catherine Guérin-Charbonnel, Hamza Lasla, Wilfried Gouraud, Jean-Luc Canon, Andrea Gombos, Florence Dalenc, Suzette Delaloge, Jérôme Lemonnier, Delphine Loussouarn, Veronique Verriele, Mario Campone. Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications. Breast Cancer Research. (2019) 65. inserm-02140196

Caroline Bodet-Milin, Clément Bailly, Yann Touchefeu, Eric Frampas, Mickaël Bourgeois, Aurore Rauscher, Franck Lacœuille, Delphine Drui, Nicolas Arlicot, David Goldenberg, Alain Faivre-Chauvet, Jacques Barbet, Caroline Rousseau, Francoise Kraeber-Bodere. Clinical Results in Medullary Thyroid Carcinoma Suggest High Potential of Pretargeted Immuno-PET for Tumor Imaging and Theranostic Approaches. Frontiers in Medicine. (2019). inserm-02167740

Stéphane Supiot, Caroline Rousseau, Mélanie Dore, Catherine Cheze-Le-Rest, Christine Kandel-Aznar, Vincent Potiron, Stéphane Guerif, François Paris, Ludovic Ferrer, Loïc Campion, Philippe Meingan, Grégory Delpon, Mathieu Hatt, Dimitris VISVIKIS. Reoxygenation during radiotherapy in intermediate-risk prostate cancer. Radiotherapy and Oncology. (2019) 16-19. inserm-02265798

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine. (2019) 85-87. inserm-02266372

Lina Benaniba, Benoit Tessoulin, Sabrina Trudel, Catherine Pellat-Deceunynck, Martine Amiot, Stephane Minvielle, Pierre Gourraud, Sophie de Visme, Hervé Maisonneuve, Anne Lok, Steven Le Gouill, Philippe Moreau, Cyrille Touzeau. The MYRACLE protocol study: a multicentric observational prospective cohort study of patients with multiple myeloma. BMC Cancer (2019) 855. inserm-02290127

Francesco Maura, Niccolo Bolli, Nicos Angelopoulos, Kevin Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodríguez-Martín, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Jose Tubio, David Wedge, Moritz Gerstung, Hervé Avet-Loiseau, Nikhil Munshi, Peter Campbell. Genomic landscape and chronological reconstruction of driver events in multiple myeloma. Nature Communications (2019) 10-1. inserm-02290176

Anil Samur, Stephane Minvielle, Masood Shammas, Mariateresa Fulciniti, Florence Magrangeas, Paul Richardson, Philippe Moreau, Michel Attal, Kenneth Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil Munshi, Mehmet Samur. Deciphering the chronology of copy number alterations in Multiple Myeloma. Blood Cancer Journal (2019) 9-4. inserm-02290251

B. Maucherat, A. Leduc-Pennec, N. Fleury, Ludovic Ferrer, E. Bourbouloux, H. Simon, M. Le Thiec, D. Rusu, V. Fleury, M. Colombie, A. Morel, Françoise Kraeber-Bodéré, Loïc Campion, Caroline Rousseau. First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients. European Journal of Nuclear Medicine and Molecular Imaging (2019). inserm-02337440

Niccolò Bolli, Francesco Maura, Stéphane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin Dawson, Mehmet Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood Shammas, Yu-Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil Alexandrov, David Wedge, Hervé Avet-Loiseau, Peter Campbell, Nikhil Munshi. Genomic patterns of progression in smoldering multiple myeloma. Nature Communications. (2018) 3363. inserm-01885513

Lydie Debaize, Hélène Jakobczyk, Stéphane Avner, Jérémie Gaudichon, Anne-Gäelle Rio, Aurélien Sérandour, Lena Dorsheimer, Frédéric Chalmel, Jason Carroll, Martin Zornig, Michael Rieger, Olivier Delalande, Gilles Salbert, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec. Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Nucleic Acids Research. (2018) 11214-11228. inserm-01885128

Bertrand Miannay, Stéphane Minvielle, Florence Magrangeas, Carito Guziolowski. Constraints on signaling network logic reveal functional subgraphs on Multiple Myeloma OMIC data. BMC Systems Biology. (2018) 32 – 32. inserm-01804825

Aurelien Serandour, Hisham Mohammed, Ahmad Miremadi, Klaas Mulder, Jason Carroll. TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers. Oncogene. (2018) 5281-5291. inserm-01814235

Eric Voog, Loïc Campion, Pauline du Rusquec, Hugues Bourgeois, Julien Domont, Fabrice Denis, Eric Emmanuel, Olivier Dupuis, Gérard Ganem, Cedrik Lafont, Katell Le Du, Elena Pavluc, Yohan Pointreau, Sophie Roche, Laurence Juhel-Voog, Marie Zinger, Philippe Solal-Celigny. Totally implantable venous access ports: a prospective long-term study of early and late complications in adult patients with cancer. Supportive Care in Cancer. (2018) 81-89. inserm-01819309

Mehmet Kemal Samur, Stéphane Minvielle, Annamaria Gulla, Mariateresa Fulciniti, Alice Cleynen, Anil Samur, Raphael Szalat, Masood Shammas, Florence Magrangeas, Yu-Tzu Tai, Daniel Auclair, Jonathan Keats, Paul Richardson, Michel Attal, Philippe Moreau, Kenneth Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil Munshi. Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma. Leukemia. (2018) Epub ahead of print. inserm-01804867

Lokmane Chebouba, Bertrand Miannay, Dalila Boughaci, Carito Guziolowski. Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming. BMC Bioinformatics. (2018) S2. hal-01988426

Patricia Gomez-Bougie, Sophie Maïga, Benoit Tessoulin, Jessie Bourcier, Antoine Bonnet, Manuel Rodriguez, Steven Le Gouill, Cyrille Touzeau, Philippe Moreau, Catherine Pellat-Deceunynck, Martine Amiot. BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment. Blood. (2018) Epub ahead of print. inserm-01900681

Cyrille Touzeau, Paulo Maciag, Martine Amiot, Philippe Moreau. Targeting Bcl-2 for the treatment of multiple myeloma. Leukemia. (2018) 1899 – 1907. inserm-01885190

Cyrille Touzeau, Philippe Moreau. Ixazomib in the management of relapsed multiple myeloma. Future Oncology. (2018) 2013 – 2020. inserm-01934497

Benoit Tessoulin, Agnès Moreau-Aubry, Géraldine Descamps, Patricia Gomez-Bougie, Sophie Maiga, Alban Gaignard, David Chiron, Emmanuelle Ménoret, Steven Le Gouill, Philippe Moreau, Martine Amiot, Catherine Pellat-Deceunynck. Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways. Journal of Hematology & Oncology. (2018) 137. inserm-01958772

Anne Lok, Géraldine Descamps, Benoit Tessoulin, David Chiron, Marion Eveillard, Catherine Godon, Yannick Le Bris, Astrid Vabret, Céline Bellanger, Laurent Maillet, Sophie Barillé-Nion, Marc Gregoire, Jean-François Fonteneau, Steven Le Gouill, Philippe Moreau, Frederic Tangy, Martine Amiot, Agnès Moreau-Aubry, Catherine Pellat-Deceunynck. p53 regulates CD46 expression and measles virus infection in myeloma cells. Blood Advances. (2018) 3492-3505. inserm-01957487

Loig Vaugier, Clément Palpacuer, Emmanuel Rio, Aurore Goineau, David Pasquier, Xavier Buthaud, Guy De Laroche, Véronique Beckendorf, Paul Sargos, Gilles Créhange, Pascal Pommier, Geneviève Loos, Ali Hasbini, Igor Latorzeff, Marlon Silva, Fabrice Denis, Jean-Léon Lagrange, Loïc Campion, Stéphane Supiot. Early toxicity of a phase II trial of combined salvage radiotherapy and hormone therapy in oligometastatic pelvic node relapses of prostate cancer (OLIGOPELVIS GETUG P07). International Journal of Radiation Oncology, Biology, Physics. (2018) 1061-1067. inserm-01980788

Vincent Fleury, Ludovic Ferrer, Mathilde Colombié, Daniela Rusu, Maëlle Le Thiec, Françoise Kraeber-Bodéré, Loïc Campion, Caroline Rousseau. Advantages of systematic trunk SPECT/CT to planar bone scan (PBS) in more than 300 patients with breast or prostate cancer. Oncotarget. (2018) 31744-31752. inserm-01885515

Stéphane Supiot, Caroline Rousseau, Mélanie Dore, Catherine Cheze-Le-Rest, Christine Kandel-Aznar, Vincent Potiron, Stéphane Guerif, François Paris, Ludovic Ferrer, Loïc Campion, Philippe Meingan, Grégory Delpon, Mathieu Hatt, Dimitris Visvikis. Evaluation of tumor hypoxia prior to radiotherapy in intermediate-risk prostate cancer using [18]F-fluoromisonidazole PET/CT: a pilot study. Oncotarget. (2018) 10005 – 10015. inserm-01823478

Aurelien A. Serandour, Stéphane Avner, Gilles Salbert. Coupling Exonuclease Digestion with Selective Chemical Labeling for Base-resolution Mapping of 5-Hydroxymethylcytosine in Genomic DNA. Bio-Protocol. (2018) 8;5. hal-02062038

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Soraya Wuilleme, Catherine Godon, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie Béné, Patrice Chevallier. Fms-like Tyrosine Kinase 3 Ligand Concentration Kinetic Profile during Induction Is Strongly Predictive of Survivals in AML: Results of the FLAM/Flal Study. Blood (2018) 1484. inserm-02341909