Tiphaine Parrot, Romain Oger, Mathilde Allard, Juliette Desfrancois, Diane Raingeard de la Blet ere, Anne Coutolleau, Laurence Preisser, Amir Khammari, Brigitte Dreno, Yves Delneste, Philippe Guardiola, Delphine Fradin, and Nadine Gervois. Transcriptomic features of tumour- in ltrating CD4 low CD8 high double positive T cells in melanoma. Scientific Reports, 2020. inserm-02534481.
Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Sha er, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen, and Nathalie Labarriere. Increased antitumor e cacy of PD-1- de cient melanoma-speci c human lymphocytes. Journal for Immunotherapy of Cancer, 2020. inserm-02481085.
Sylvain Simon, Valentin Voillet, Virginie Vignard, Zhong Wu, Camille Dabrowski, Nicolas Jouand, Tiffany Beauvais, Amir Khammari, Cecile Braudeau, Regis Josien, Olivier Adotevi, Caroline La-heurte, Francois Aubin, Charles Nardin, Samuel Rulli, Raphael Gottardo, Nirasha Ramchurren, Martin Cheever, Steven P Fling, Candice D Church, Paul Nghiem, Brigitte Dreno, Stanley R Rid-dell, and Nathalie Labarriere. PD-1 and TIGIT coexpression identi es a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy. Journal for Immunotherapy of Cancer, 2020. inserm-03011429.
Amir Khammari, Jean-Michel Nguyen, Marie-Therese Leccia, Bernard Guillot, Soraya Sa agh, Marie-Christine Pandol no, Anne-Chantal Knol, Gaelle Quereux, Anne Chiffolettau, Nathalie Labarriere, and Brigitte Dreno. Tumor in ltrating lymphocytes as adjuvant treatment in stage III melanoma patients with only one invaded lymph node after complete resection: results from a multicentre, randomized clinical phase III trial. Cancer Immunology, Immunotherapy, 2020. inserm-02873869.
Aurelie Fluckiger, Romain Daillere, mohamed sassi, Barbara S Sixt, Peng Liu, Friedemann Loos, Corentin Richard, Catherine Rabu, Maryam Tidjani, Anne-Gaelle Goubet, Fabien Lemaitre, Gladys Ferrere, Lisa Derosa, Connie Duong, Meriem Messaoudene, Andreanne Gagne, Philippe Joubert, Luisa De Sordi, Laurent Debarbieux, Sylvain Simon, Clara-Maria Scarlata, Maha Ayyoub, Belinda Palermo, Francesco Facciolo, Romain Boidot, Richard Wheeler, Ivo Gomperts Boneca, Zso a Sz-tupinszki, Krisztian Papp, Istvan Csabai, Edoardo Pasolli, Nicola Segata, Carlos Lopez-Ot n, Zoltan Szallasi, Fabrice Andre, Valerio Iebba, Valentin Quiniou, David Klatzmann, Jacques Boukhalil, Saber Khelai a, Didier Raoult, Laurence Albiges, Bernard Escudier, Alexander M Eggermont, Fathia Mami-Chouaib, Paola Nistico, Francois Ghiringhelli, Bertrand Routy, Nathalie Labarriere, Vincent Cattoir, Guido E Kroemer, and Laurence Zitvogel. Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Science, 2020. inserm-02923397.
Catherine Rabu, Laurie Rangan, Laetitia Florenceau, Agnès Fortun, Maud Charpentier, Emilie Dupré, Léa Paolini, Céline Beauvillain, Estelle Dupel, Jean-Baptiste Latouche, Olivier Adotévi, Nathalie Labarrière, François Lang. Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells. OncoImmunology. (2019) e1560919-2. inserm-01991877
Juliette Eugène, Nicolas Jouand, Kathleen Ducoin, Delphine Dansette, Romain Oger, Cécile Deleine, Edouard Leveque, Guillaume Meurette, Juliette Podevin, Tamara Matysiak, Jaafar Bennouna, Stéphane Bézieau, Christelle Volteau, Wassila El Alami Thomas, Jérôme Chetritt, Olivier Kerdraon, Pierre Fourquier, Emilie Thibaudeau, Frédéric Dumont, Jean-François Mosnier, Claire Toquet, Anne Jarry, Nadine Gervois, Céline Bossard. The inhibitory receptor CD94/NKG2A on CD8 + tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression. Modern Pathology. (2019) Epub ahead of print. inserm-02281341
Mahtab Samimi, Houssem Benlalam, Pascal Aumond, Pauline Gaboriaud, Delphine Fradin, Thibault Kervarrec, Laetitia Florenceau, Virginie Vignard, Astrid Blom, Antoine Touzé, Nadine Gervois, Nathalie Labarrière. Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma. Cellular Immunology (2019) 103961 inserm-02284748
Eva Ott, Linda Bilonda, Delphine Dansette, Cécile Deleine, Emilie Duchalais, Juliette Podevin, Christelle Volteau, Jaafar Bennouna, Yann Touchefeu, Pierre Fourquier, Wassila El Alami Thomas, Jérome Chetritt, Stéphane Bezieau, Marc Denis, Claire Toquet, Jean-François Mosnier, Anne Jarry, Céline Bossard. The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status. OncoImmunology. (2019) e1562834. inserm-02100125
Catherine Le Stunff, Anne-Laure Castell, Nicolas Todd, Clémence Mille, Marie-Pierre Belot, Nathalie Frament, Sylvie Brailly-Tabard, Alexandra Benachi, Delphine Fradin, Pierre Bougnères. Fetal growth is associated with the CpG methylation of the P2 promoter of the IGF1 gene. Clinical Epigenetics. (2018) 57. inserm-01782203
Virginie Vignard, Delphine Fradin. Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Dissemination. OBM Genetics. (2018) 1-1. inserm-01804848
Nicolas Jouand, Céline Bressollette-Bodin, Nathalie Gérard, Magali Giral, Pierrick Guérif, Audrey Rodallec, Romain Oger, Tiphaine Parrot, Mathilde Allard, Anne Cesbron-Gautier, Nadine Gervois, Béatrice Charreau. HCMV triggers frequent and persistent UL40- specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition. PLoS Pathogens. (2018) e1007041. inserm-01812003
Chantal Bou-Hanna, Anne Jarry, Jean-François Mosnier, Céline Bossard, Christian Laboisse. The double stranded RNA analog poly-IC elicits both robust IFN-λ production and oncolytic activity in human gastrointestinal cancer cells. Oncotarget. (2018) 34471 – 34484. inserm-01938002
Camille Martin-Gallausiaux, Pierre Larraufie, Anne Jarry, Fabienne Beguet-Crespel, Ludovica Marinelli, Florence Ledue, Frank Reimann, Herve Blottiere, Nicolas Lapaque. Butyrate produced by commensal bacteria down-regulates indolamine 2, 3-dioxygenase 1 (IDO-1) expression via a dual mechanism in human intestinal epithelial cells. Frontiers in Immunology. (2018) 2838. inserm-01937996
Marie-Laure Vuillaume, Mederic Jeanne, Li Xue, Sophie Blesson, Anne-Sophie Denomme-Pichon, Servane Alirol, Celine Brulard, Estelle Colin, Bertrand Isidor, Brigitte Gilbert-Dussardier, Sylvie Odent, Philippe Parent, Audrey Donnart, Richard Redon, Stéphane Bézieau, Philippe Rondard, Frederic Laumonnier, Annick Toutain. A novel mutation in the transmembrane 6 domain of GABBR2 leads to a Rett-like phenotype. Annals of Neurology. (2018) 437-439. hal-01730199
Tilda Passat, Yann Touchefeu, Nadine Gervois, Anne Jarry, Céline Bossard, Jaafar Bennouna. Physiopathological mechanisms of immune-related adverse events induced by anti-CTLA-4, anti-PD-1 and anti-PD-L1 antibodies in cancer treatment. Bulletin du Cancer. (2018) 1033-1041. inserm-01981595
Nicolas Jouand, Céline Bressollette-Bodin, Nathalie Gérard, Magali Giral, Pierrick Guerif, Audrey Rodallec, Romain Oger, Tiphaine Parrot, Anne Cesbron-Gautier, Nadine Gervois, Béatrice Charreau. Deciphering anti-HCMV HLA-E-restricted unconventional CD8 T-cell responses in seropositive HCMV+ hosts. [Poster]. (2018) np. inserm-02158889
Emilie Dugast, Gaëlle David, Romain Oger, Richard Danger, Jean-Paul Judor, Katia Gagne, Mélanie Chesneau, Nicolas Degauque, Jean-Paul Soulillou, Pascale Paul, Christophe Picard, Pierrick Guerif, Sophie Conchon, Magali Giral, Nadine Gervois, Christelle Retière, Sophie Brouard. Corrigendum: Broad Impairment of Natural Killer Cells From Operationally Tolerant Kidney Transplanted Patients. Frontiers in Immunology. (2018) 589. inserm-01811913
Jocelyn Ollier, Thibault Kervarrec, Mahtab Samimi, Houssem Benlalam, Pascal Aumont, Régine Vivien, Antoine Touzé, Nathalie Labarrière, Henri Vié, Béatrice Clémenceau. Merkel cell carcinoma and cellular cytotoxicity: sensitivity to cellular lysis and screening for potential target antigens suitable for antibodydependent cellular cytotoxicity. Cancer Immunology, Immunotherapy. (2018) Epub ahead of print. inserm-01807689
Sylvain Simon, Zhong Wu, J. Cruard, Virginie Vignard, Agnès Fortun, Amir Khammari, Brigitte Dréno, Francois Lang, Samuel Rulli, Nathalie Labarrière. TCR Analyses of Two Vast and Shared Melanoma Antigen-Specific T Cell Repertoires: Common and Specific Features. Frontiers in Immunology. (2018) 1962. inserm-01885141
Emmanuelle Godefroy, Joudy Alameddine, Emmanuel Montassier, Justine Mathé, Juliette Desfrançois-Noël, Nadège Marec, Céline Bossard, Anne Jarry, Chantal Bridonneau, Amandine Le Roy, Guillaume Sarrabayrouse, Elise Kerdreux, Arnaud Bourreille, Harry Sokol, Francine Jotereau, Frédéric Altare. Expression of CCR6 and CXCR6 by Gut-Derived CD4+/CD8α+ T-Regulatory Cells, Which Are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases. Gastroenterology. (2018) 1205-1217. inserm-01968888
Léa Paolini, Caroline Poli, Simon Blanchard, Thierry Urban, Anne Croué, Marie-Christine Rousselet, Sarah Le Roux, Nathalie Labarrière, Pascale Jeannin, José Hureaux. Thoracic and cutaneous sarcoid-like reaction associated with anti-PD-1 therapy: longitudinal monitoring of PD-1 and PD-L1 expression after stopping treatment. Journal for Immunotherapy of Cancer. (2018) 52. inserm-01817689
Tiphaine Delaunay, Mathilde Violland, Nicolas Boisgerault, Soizic Dutoit, Virginie Vignard, Christian Münz, Monique Gannagé, Brigitte Dréno, Kristine Vaivode, Dace Pjanova, Nathalie Labarrière, Yaohe Wang, E Chiocca, Fabrice Le Boeuf, John Bell, Philippe Erbs, Frédéric Tangy, Marc Grégoire, Jean-François Fonteneau. Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells. OncoImmunology. (2017). inserm-01644345
Sylvain Simon, Virginie Vignard, Emilie Varey, Tiphaine Parrot, Anne-Chantal Knol, Amir Khammari, Nadine Gervois, François Lang, Brigitte Dréno, Nathalie Labarrière. Emergence of High-Avidity Melan-A–Specific Q2 Clonotypes as a Reflection of Anti–PD-1 Q3 Clinical Efficacy. Cancer Research. (2017) 7083 – 7093. inserm-01636933
Sylvain Simon, Nathalie Labarrière. PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?. OncoImmunology. (2017). inserm-01592666
Sylvain Simon, Maud Charpentier, Ignacio Anegon, Nathalie Labarrière. Conference Scenes: Immunotherapies in transplantation and cancer. Immunotherapy. (2017) Epub ahead of print. inserm-01639012
Sylvain Simon, Maud Charpentier, Ignacio Anegon, Nathalie Labarrière. Immunotherapies in transplantation and cancer: 22nd NAT meeting/2nd NAT LabEx IGO joint meeting; 1–2 June 2017, Nantes, France. Cancer Immunology, Immunotherapy. (2017) 867-870. inserm-02153746
Sébastien Küry, Thomas Besnard, Frédéric Ebstein, Tahir N. Khan, Tomasz Gambin, Jessica Douglas, Carlos A. Bacino, Stephan J. Sanders, Andrea Lehmann, Xenia Latypova, Kamal Khan, Mathilde Pacault, Stephanie Sacharow, Kimberly Glaser, Eric Bieth, Laurence Perrin-Sabourin, Marie-Line Jacquemont, Megan T. Cho, Elizabeth Roeder, Anne-Sophie Denommé-Pichon, Kristin G. Monaghan, Bo Yuan, Fan Xia, Sylvain Simon, Dominique Bonneau, Philippe Parent, Brigitte Gilbert-Dussardier, Sylvie Odent, Annick Toutain, Laurent Pasquier, Deborah Barbouth, Chad A. Shaw, Ankita Patel, Janice L. Smith, Weimin Bi, Sébastien Schmitt, Wallid Deb, Mathilde Nizon, Sandra Mercier, Marie Vincent, Caroline Rooryck, Valérie MALAN, Ignacio Briceno, Alberto Gómez, Kimberly M. Nugent, James B. Gibson, Benjamin Cogné, James R. Lupski, Holly A. F. Stessman, Evan E. Eichler, Kyle Retterer, Yaping Yang, Richard Redon, Nicholas Katsanis, Jill A. Rosenfeld, Peter-Michael Kloetzel, Christelle Golzio, Stéphane Bézieau, Paweł Stankiewicz, Bertrand Isidor. De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder. American Journal of Human Genetics. (2017) 352-363. hal-01478814
Laurence Zitvogel, Eric Vivier, Frederic Vely, Florence Faure, Brigitte Dréno, Houssem Benlalam, Fanny Bouquet, Ariel Savina, Eric Pasmant, Antoine Toubert, Marie-Francoise Avril, Anne Caignard, Alexandra Frazao, Marina Colombo, Emmanuelle Fourmentraux-Neves, Meriem Messaoudene, Sylvie Rusakiewicz. Shifting the Balance of Activating and Inhibitory Natural Killer Receptor Ligands on BRAF(V600E) Melanoma Lines with Vemurafenib. Cancer Immunology Research. (2017) 582-593. hal-01996164
Emilie Dugast, Gaëlle David, Romain Oger, Richard Danger, Jean-Paul Judor, Katia Gagne, Mélanie Chesneau, Nicolas Degauque, Pascale Paul, Christophe Picard, Pierrick Guerif, Sophie Conchon, Magali Giral, Nadine Gervois, Christelle Retière, Sophie Brouard. Broad Impairment of Natural Killer Cells from Operationally Tolerant Kidney Transplanted Patients. Frontiers in Immunology. (2017) 1721. hal-01712225
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