2020 2019 2018 2017


Josephine Briand, Aurelien A Serandour, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Dominique Heymann, Benjamin Ory, Francois M. Vallette, and Pierre-Francois Cartron. N6-Adenosine Methylation of miRNA-200b-3p In uences Its Functionality and Is a Theranostic Tool. Molecular Therapy – Nucleic Acids, 2020. hal-03004313.

Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denie, Catherine Guerin-Charbonnel, Loïc Campion, Michel Attal, Herve Avet-Loiseau, Thomas Carell, Philippe Moreau, Stephane Minvielle, and Aurelien A Serandour. DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clinical Epigenetics, 2020. inserm-03006751.

Celine Salaud, Arturo Alvarez-Arenas, Fanny Geraldo, Juan Belmonte-Beitia, Gabriel F Calvo, Catherine Gratas, Claire Pecqueur, Delphine Garnier, Victor Perez-Garcia, Francois M Vallette, and Lisa Oliver. Mitochondria transfer from tumor-activated stromal cells (TASC) to primary Glioblas-toma cells. Biochemical and Biophysical Research Communications, 2020. inserm-03013565.

Kristell Oizel, Chendong Yang, Ophelie Renoult, Fabien Gautier, Quyen N Do, Noemie Joalland, Xiaofei Gao, Bookyung Ko, Francois Vallette, Woo-Ping Ge, Francois Paris, Ralph J Deberardinis, and Claire Pecqueur. Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model. Cancer and Metabolism, 2020. inserm-03013555.

Fabrice Chatonnet, Amandine Pignarre, Aurelien Serandour, Gersende Caron, Stephane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, Jose Martin-Subero, Jerome Moreaux, Thierry Fest, and Gilles Salbert. The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation. Haematologica, 2020. hal -02165596.

Marion Rabe, Solenne Dumont, Arturo Alvarez-Arenas, Hicham Janati, Juan Belmonte-Beitia, Gabriel F Calvo, Christelle Thibault-Carpentier, Quentin Sery, Cynthia Chauvin, Noemie Joalland, Floriane Briand, Stephanie Blandin, Emmanuel Scotet, Claire Pecqueur, Jean Clairambault, Lisa Oliver, Victor Perez-Garcia, Arulraj M Nadaradjane, Pierre-Francois Cartron, Catherine Gratas, and Francois Vallette. Identfication of a transient state during the acquisition of temozolomide resistance in glioblastoma. Cell Death and Disease, 2020. hal-02429194.

Maureen Labbe, Christianne Hoey, Jessica Ray, Vincent Potiron, Stephane Supiot, Stanley K Liu, and Delphine Fradin. microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation. Molecular Cancer, 2020. inserm-02515300.

Vincent Mignard, Nolwenn Dubois, Didier Lanoe, Marie-Pierre M Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, Francois Paris, Francois M Vallette, and Lisenn Lalier. Sph-ingolipids distribution at mitochondria-associated membranes (MAM) upon induction of apop-tosis. Journal of Lipid Research, 2020. inserm-02625440.

Victor Perez-Garcia, Gabriel F Calvo, Jesus J Bosque, Odelaisy Leon-Triana, Juan Jimenez, Julian Perez-Beteta, Juan Belmonte-Beitia, Manuel Valiente, Lucia Zhu, Pedro Garcia-Gomez, Pilar Sanchez-Gomez, Esther Hernandez-San Miguel, Rafael Hortiguela, Youness Azimzade, David Molina-Garcia, Alvaro Martinez, Angel Acosta Rojas, Ana Ortiz de Mendivil, Francois M. Vallette, Philippe Schucht, Michael Murek, Maria Perez-Cano, David Albillo, Antonio F Honguero Martinez, German A Jimenez Londono, Estanislao Arana, and Ana Garcia Vicente. Universal scaling laws rule explosive growth in human cancers. Nature Physics, 2020. inserm-02913972.

Manon Duforestel, Josephine Briand, Gwenola Bougras-Cartron, Dominique Heymann, Jean Sebastien Frenel, Francois M. Vallette, and Pierre-Francois Cartron. Cell-free circulating epimarks in cancer monitoring. Epigenomics, 2020. inserm-02484725.

Lisa Oliver, Lisenn Lalier, Celine Salaud, Dominique Heymann, Pierre Francois Cartron, and Francois M. Vallette. Drug resistance in glioblastoma: are persisters the key to therapy? Cancer Drug Resistance, 2020. inserm-02913818.

Karen Clement-Colmou, Vincent A. Potiron, Manon Pietri, Maeva Guillonneau, Emmanuel Jouglar, Sophie Chiavassa, Gregory Delpon, Francois Paris, and Stephane Supiot. In uence of Radiother-apy Fractionation Schedule on the Tumor Vascular Microenvironment in Prostate and Lung Cancer Models. Cancers, 2020. inserm-02426486.

Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Josephine Briand, Farida Akcha, Dominique Heymann, Francois M Vallette, Jean Mosser, Benjamin Ory, and Pierre-Francois Cartron. Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme. Molecular Cancer, 2020. hal-02500622.

Stephanie Grandemange, Antonio Monari, Philippe Gros, and Pierre-Francois Cartron. Utilisation d’un compose organometallique en tant que qu’agent de demethylation de l’ADN, 2020. hal-02987504.


Kristina Schiavone, Delphine Garnier, Marie Françoise Heymann, Dominique Heymann. The heterogeneity of osteosarcoma: the role played by cancer stem cells. Advances in Experimental Medicine and Biology. (2019). hal-02078118

Fabrice Chatonnet, Amandine Pignarre, Aurelien Serandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José Martin-Subero, Jerome Moreaux, Thierry Fest, Gilles Salbert. The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation. Haematologica. (2019) haematol.2019.222133. hal-02165596

Marta Tellez-Gabriel, Marie-Françoise Heymann, Dominique Heymann. Circulating tumor cells as a tool for assessing tumor heterogeneity. Theranostics. (2019) Epub ahead of print. inserm-02110266

Julien Fleurence, Meriem Bahri, Sophie Fougeray, Sébastien Faraj, Sarah Vermeulen, Émilie Pinault, Fanny Geraldo, Lisa Oliver, Joëlle Véziers, Pierre Marquet, Marion Rabé, Catherine Gratas, François Vallette, Claire Pecqueur, François Paris, Stéphane Birklé. Impairing Temozolomide Resistance Driven by Glioma Stem-like Cells with adjuvant Immunotherapy Targeting O-acetyl GD2 Ganglioside. International Journal of Cancer. (2019) Epub ahead of print. inserm-02168202

Delphine Garnier, Ophélie Renoult, Marie-Clotilde Alves-Guerra, François Paris, Claire Pecqueur. Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target. Frontiers in Oncology. (2019) 118. inserm-02240417

Vincent Potiron, Karen Clément-Colmou, Emmanuel Jouglar, Manon Pietri, Sophie Chiavassa, Grégory Delpon, François Paris, Stéphane Supiot. Tumor vasculature remodeling by radiation therapy increases doxorubicin distribution and efficacy. Cancer Letters. (2019) 1-9. inserm-02265795

Stéphane Supiot, Caroline Rousseau, Mélanie Dore, Catherine Cheze-Le-Rest, Christine Kandel-Aznar, Vincent Potiron, Stéphane Guerif, François Paris, Ludovic Ferrer, Loïc Campion, Philippe Meingan, Grégory Delpon, Mathieu Hatt, Dimitris Visvikis. Reoxygenation during radiotherapy in intermediate-risk prostate cancer. Radiotherapy and Oncology. (2019) 16-19. inserm-02265798

Aurélie Ginisty, Lisa Oliver, Patricia Arnault, François Vallette, Omar Benzakour, Valérie Coronas. The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells. European Journal of Pharmacology. (2019) 30-39. inserm-02265838

Manon Duforestel, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Josephine Briand, Christophe Olivier, Jean-Sébastien Frenel, François Vallette, Sophie Lelièvre, Pierre-François Cartron. Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner. Frontiers in Genetics (2019). inserm-02309615

Josephine Briand, Marie-Pierre Joalland, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Christophe Olivier, François Vallette, Sylvain Perruche, Pierre-Francois Cartron. Diuron modulates the DNA methylation status of the ILT7 and TRAIL/TNFSF10 genes and decreases the killing activity of plasmacytoid dendritic cells. Environmental Sciences Europe (2019). 31-1. inserm-02309623

Cynthia Chauvin, Noémie Joalland, Jeanne Perroteau, Ulrich Jarry, Laura Lafrance, Catherine Willem, Christelle Retiere, Lisa Oliver, Catherine Gratas, Laetitia Gautreau-Rolland, Xavier Saulquin, François Vallette, Henri Vie, Emmanuel Scotet, Claire Pecqueur. NKG2D controls natural reactivity of Vγ9Vδ2 T lymphocytes against mesenchymal glioblastoma cells. Clinical Cancer Research (2019). inserm-02316604

Simon Valès, Gregory Bacola, Mandy Biraud, Mélissa Touvron, Anne Bessard, Fanny Geraldo, Kelsie Dougherty, Shaian Lashani, Céline Bossard, Mathurin Flamant, Emilie Duchalais, Séverine Marionneau-Lambot, Thibauld Oullier, Lisa Oliver, Michel Neunlist, François Vallette, Laurianne van Landeghem. Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis. EBioMedicine (2019). inserm-02337834


Jorge Vargas-Franco, Beatriz Castaneda, Françoise Rédini, David Francisco Gómez, Dominique Heymann, Frederic Lezot. Paradoxical side effects of bisphosphonates on the Skeleton : What do we know and what can we do ? Journal of Cellular Physiology. (2018) Epub ahead of print. inserm-01693313

Yolanda González-Fernández, Hannah Brown, Ana Patiño-García, Dominique Heymann, María Blanco-Prieto. Oral edelfosine lipid nanoparticles caused the regression of lung metastases in pre- clinical osteosarcoma animal models. Cancer Letters. (2018) 193 – 200. inserm-01803295

Marja Steenman, Olivier espetia, Blandine Maurel, Béatrice Guyomarch, Marie-Françoise Heymann, Marc-Antoine Pistorius, Benjamin Ory, Dominique Heymann, Rémi Houlgatte, Yann Gouëffic, Thibaut Quillard. Identification of genomic differences among peripheral arterial beds in atherosclerotic and healthy arteries. Scientific Reports. (2018) 3940. inserm-01725150

Daniëlle de Ridder, Silvia Marino, Ryan Bishop, Nathalie Renema, Chantal Chenu, Dominique Heymann, Aymen Idris. Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A. Scientific Reports. (2018) 6877. inserm-01792163

Delphine Garnier, Ruoya Li, Frédéric Delbos, Angélique Fourrier, Camille Collet, Christiane Guguen-Guillouzo, Christophe Chesné, Tuan Huy Nguyen. Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system. Scientific Reports. (2018) 8222 – 8222. inserm-01810195

Delphine Garnier, Brian Meehan, Thomas Kislinger, Paul Daniel, Ankit Sinha, Bassam Abdulkarim, Ichiro Nakano, Janusz Rak. Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization. Neuro-Oncology. (2018) 236 – 248. inserm-01814308

Benjamin Navet, Jorge Vargas-Franco, Andrea Gama, Jerome Amiaud, Yongwon Choi, Hideo Yagita, Christopher Mueller, Françoise Rédini, Dominique Heymann, Beatriz Castaneda, Frédéric Lézot. Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups. Journal of Clinical Medicine Research. (2018) E426. inserm-01923428

The Milieu Intérieur Consortium, Stephanie Kilens, Dimitri Meistermann, Diego Moreno, Caroline Chariau, Anne Gaignerie, Arnaud Reignier, Yohann Lelièvre, Miguel Casanova, Céline Vallot, Steven Nedellec, Léa Flippe, Julie Firmin, Juan Song, Eric Charpentier, Jenna Lammers, Audrey Donnart, Nadège Marec, Wallid Deb, Audrey Bihouee, Cédric Le Caignec, Claire Pecqueur, Richard Redon, Paul Barriere, Jérémie Bourdon, Vincent Pasque, Magali Soumillon, Tarjei S Mikkelsen, Claire Rougeulle, Thomas Freour, Laurent David. Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature Communications. (2018) 487. hal-01881146

Camille Jacques, Nathalie Renema, Frédéric Lézot, Benjamin Ory, Carl Walkley, Agamemnon Grigoriadis, Dominique Heymann. Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations. Journal of Bone Oncology. (2018) 7-13. inserm-01814330

Antoine Chalopin, Marta Tellez-Gabriel, Hannah Brown, Francois Vallette, Marie Françoise Heymann, Dominique Heymann. Isolation of circulating tumor cells in a preclinical model of osteosarcoma: effect of chemotherapy. Journal of Bone Oncology. (2018) 83-90. inserm-01851614

Hannah Brown, Marta Tellez-Gabriel, Pierre-François Cartron, François Vallette, Marie-Françoise Heymann, Dominique Heymann. Characterization of circulating tumor cells as a reflection of the tumor heterogeneity: myth or reality? Drug Discovery Today Biosilico. (2018) Epub ahead of print. inserm-01947472

Eric Hervouet, Paul Peixoto, Régis Delage-Mourroux, Michaël Boyer-Guittaut, Pierre-François Cartron. Specific or not specific recruitment of DNMTs for DNA methylation, an epigenetic dilemma. Clinical Epigenetics. (2018) 17. inserm-01981717

Josephine Briand, Arulraj Nadaradjane, François Vallette, Pierre Cartron. The TET2 Expression Level Correlates with a Short Relapse Time in Glioblastoma Multiforme. Journal of Clinical Epigenetics / J Clin Epigenet. (2018) 12. inserm-01981842

Marta Tellez-Gabriel, Denis Cochonneau, Marie Cadé, Camille Jubelin, Marie-Françoise Heymann, Dominique Heymann. Circulating Tumor Cell-Derived Pre-Clinical Models for Personalized Medicine. Cancers. (2018) epub ahead of print. inserm-01964962

Steven Georges, Lidia Calleja, Camille Jacques, Melanie Lavaud, Brice Moukengue, Fernando Lecanda, Thibaut Quillard, Marta Gabriel, Pierre-François Cartron, Marc Baudéposhuin, François Lamoureux, Dominique Heymann, Benjamin Ory. Loss of miR-198 and-206 during primary tumor progression enables metastatic dissemination in human osteosarcoma. Oncotarget. (2018) 35726 – 35741. inserm-01982044

Arulraj Nadaradjane, Joséphine Briand, Gwenola Bougras-Cartron, Valentine Disdero, François Vallette, Jean-Sébastien Frenel, Pierre-François Cartron. miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker. Molecular Therapy – Nucleic Acids. (2018) 642-650. inserm-01982015

Catherine Boisson-Vidal, Zahia Benslimane-Ahmim, Anna Lokajczyk, Dominique Heymann, David Smadja. Osteoprotegerin induces CD34 + differentiation in Endothelial Progenitor Cells. Frontiers in Medicine. (2018) 331. inserm-01965981

François Vallette, Christophe Olivier, Frederic Lezot, Lisa Oliver, Denis Cochonneau, Lisenn Lalier, François Cartron, Dominique Heymann. Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer. Biochemical Pharmacology. (2018) Epub ahead of print. inserm-01947474

Stéphanie Kilens, Dimitri Meistermann, Diego Moreno, Caroline Chariau, Anne Gaignerie, Arnaud Reignier, Yohann Lelièvre, Miguel Casanova, Céline Vallot, Steven Nedellec, Léa Flippe, Julie Firmin, Juan Song, Eric Charpentier, Jenna Lammers, Audrey Donnart, Nadège Marec, Wallid Deb, Audrey Bihouée, Cédric Le Caignec, Claire Pecqueur, Richard Redon, Paul Barriere, Jérémie Bourdon, Vincent Pasque, Magali Soumillon, Tarjei Mikkelsen, Claire Rougeulle, Thomas Freour, Laurent David, Milieu Intérieur Consortium. Parallel derivation of isogenic human primed and naive induced pluripotent stem cells. Nature Communications. (2018) 302 – 314. pasteur-01758726

Noémie Joalland, Cynthia Chauvin, Lisa Oliver, François Vallette, Claire Pecqueur, Ulrich Jarry, Emmanuel Scotet. IL-21 Increases the Reactivity of Allogeneic Human Vγ9Vδ2 T Cells Against Primary Glioblastoma Tumors. Journal of immunotherapy : official journal of the Society for Biological Therapy. (2018) 224-231. inserm-01804994

Ulrich Jarry, Noémie Joalland, Cynthia Chauvin, Beatrice Clemenceau, Claire Pecqueur, Emmanuel Scotet. Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts. Journal of visualized experiments : JoVE. (2018) 1(139). inserm-01885088

Christophe Blanquart, Camille Linot, Pierre-François Cartron, Daniela Tomaselli, Antonello Mai, Philippe Bertrand. Epigenetic metalloenzymes. Current Medicinal Chemistry. (2018) 1-36. inserm-01885512


Quentin Séry, Marion Rabé, Lisa Oliver, François Vallette, Catherine Gratas. HB-EGF is associated with DNA damage and Mcl-1 turnover in human glioma cell lines treated by Temozolomide. Biochemical and Biophysical Research Communications. (2017) 1377 – 1383. inserm-01813093

Peter Ratcliffe, Peppi Koivunen, Johanna Myllyharju, Jiannis Ragoussis, Judith Bovée, Ines Batinic-Haberle, Claire Vinatier, Valérie Trichet, Florence Robriquet, Lisa Oliver, Betty Gardie. Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics. Hypoxia. (2017) inserm-01845039

Kristell Oizel, Cynthia Chauvin, Lisa Oliver, Catherine Gratas, Fanny Geraldo, Ulrich Jarry, Emmanuel Scotet, Marion Rabe, Marie-Clotilde Alves-Guerra, Raluca Teusan, Fabien Gautier, Delphine Loussouarn, Vincent Compan, Jean-Claude Martinou, François Vallette, Claire Pecqueur. Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity. Clinical Cancer Research. (2017) Epub ahead of print. inserm-01595798

Julien Fleurence, Sophie Fougeray, Meriem Bahri, Denis Cochonneau, Béatrice Clémenceau, François Paris, Andras Heczey, Stéphane Birklé. Targeting-Acetyl-GD2 Ganglioside for Cancer Immunotherapy. Journal of Immunology Research. (2017) [Epub ahead of print]. inserm-01474322

Judith Raimbourg, Marie-Pierre Joalland, Mathilde Cabart, Ludmilla dePlater, Fanny Bouquet, Ariel Savina, Didier Decaudin, Jaafar Bennouna,François Vallette, Lisenn Lalier. Sensitization of EGFR wild-type non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitor erlotinib.. Molecular Cancer Therapeutics. (2017) 1634-1644. inserm-01525974

Hannah Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann. Biology of bone sarcomas and new therapeutic developments. Calcified Tissue International. (2017) inserm-01653600

Elizabeth Harford-Wright, Gwennan André-Grégoire, Kathryn Jacobs, Lucas Treps, Sophie Le Gonidec, Héloïse Leclair, Sara Gonzalez-Diest, Quentin Roux, François Guillonneau, Delphine Loussouarn, Lisa Oliver, François Vallette, Fabienne Foufelle, Philippe Valet, Anthony Davenport, Robert Glen, Nicolas Bidère, Julie Gavard. Pharmacological targeting of apelin impairs glioblastoma growth. Brain – A Journal of Neurology. (2017) Epub ahead of print. inserm-01611131

Cristina Bagacean, Adrian Tempescul, Christelle Le Dantec, Anne Bordron, Audrey Mohr, Hussam Saad, Valerie Olivier, Mihnea Zdrenghea, Victor Cristea, Pierre-François Cartron, Nathalie Douet-Guilbert, Christian Berthou, Yves Renaudineau. Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia. Oncotarget. (2017) hal-01573947