Publications 2019 - CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes Angers

PUBLICATIONS DE 2019

EQUIPE 1 EQUIPE 2 EQUIPE 3 EQUIPE 4 EQUIPE 5 EQUIPE 6 EQUIPE 7 EQUIPE 8 EQUIPE 9

EQUIPE 10 EQUIPE 11 EQUIPE 12 EQUIPE 13 EQUIPE 14 EQUIPE 15 EQUIPE 16 EQUIPE 17

EQUIPE 1

Yoan Brissonnet, Coralie Assailly, Amelie Saumonneau, Julie Bouckaert, Mike Maillasson, Clemence Petitot, Benoit Roubinet, Blanka Didak, Ludovic Landemarre, Clarisse Bridot, Ralf Blossey, David Deniaud, Xibo Yan, Julien Bernard, Charles Tellier, Cyrille Grandjean, Franck Daligault, Sebastien G. Gouin. Multivalent Thiosialosides and Their Synergistic Interaction with Pathogenic Sialidases. Chemistry – A European Journal. (2019) 2358-2365. hal-02140863

Louise Bouard, Caroline Bodet-Milin, Clément Bailly, Thierry Guillaume, Pierre Peterlin, Alice Garnier, Amandine Bourgeois, Béatrice Mahé, Viviane Dubruille, Nicolas Blin, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Antoine Bonnet, Marie Bene, Steven Gouill, Philippe Moreau, Françoise Kraeber-Bodéré, Patrice Chevallier. Deauville Scores 4 or 5 Assessed by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Early Post-Allotransplant Is Highly Predictive of Relapse in Lymphoma Patients. Biology of Blood and Marrow Transplantation. (2019) 906-911. inserm-01981440

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-Christine Béné, Patrice Chevallier. FLT3 ligand plasma levels in acute myeloid leukemia. Haematologica. (2019) Epub ahead of print. inserm-01993986

Thierry Guillaume, Virginie Dehame, Patrice Chevallier, Pierre Peterlin, Alice Garnier, Marc Grégoire, Edward Pichinuk, Daniel Rubinstein, Daniel Wreschner. Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies. Experimental Hematology. (2019) 97-108. inserm-01994077

Catherine Willem, Dhon Roméo Makanga, Thierry Guillaume, Bercelin Maniangou, Nolwenn Legrand, Katia Gagne, Pierre Peterlin, Alice Garnier, Marie Béné, Anne Cesbron, Amandine Le Bourgeois, Patrice Chevallier, Christelle Retière. Impact of KIR/HLA Incompatibilities on NK Cell Reconstitution and Clinical Outcome after T Cell–Replete Haploidentical Hematopoietic Stem Cell Transplantation with Posttransplant Cyclophosphamide. Journal of Immunology. (2019) 2141-2152. inserm-02080762

Michael Dustin, Emmanuel Scotet, Daniel Olive. An X-ray Vision for Phosphoantigen Recognition. Immunity. (2019) 1026-1028. inserm-02102425

Marie-Claire Devilder, Melinda Moyon, Laetitia Gautreau-Rolland, Benjamin Navet, Jeanne Perroteau, Florent Delbos, Marie-Claude Gesnel, Richard Breathnach, Xavier Saulquin. Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies. BMC Biotechnology. (2019). inserm-02117156

Christelle Harly, Devin Kenney, Gang Ren, Binbin Lai, Tobias Raabe, Qi Yang, Margaret Cam, Hai-Hui Xue, Keji Zhao, Avinash Bhandoola. The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage. Nature Immunology. (2019) Epub ahead of print. inserm-02265827

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine. (2019) 85-87. inserm-02266372

Rui Sousa, Adèle Laurent, Agnès Quéméner, Erwan Mortier, Jean-Yves Le Questel. Mechanistic and Structural Insights on the IL-15 System through Molecular Dynamics Simulations. Molecules (2019) 3261. inserm-02289307

Marie Frutoso, Erwan Mortier. NK Cell Hyporesponsiveness: More Is Not Always Better. International Journal of Molecular Sciences. (2019) 4514. inserm-02289319

Cynthia Chauvin, Noémie Joalland, Jeanne Perroteau, Ulrich Jarry, Laura Lafrance, Catherine Willem, Christelle Retiere, Lisa Oliver, Catherine Gratas, Laetitia Gautreau-Rolland, Xavier Saulquin, François Vallette, Henri Vie, Emmanuel Scotet, Claire Pecqueur. NKG2D controls natural reactivity of Vγ9Vδ2 T lymphocytes against mesenchymal glioblastoma cells. Clinical Cancer Research (2019). inserm-02316604

Agnès Quéméner, Sébastien Morisseau, Rui Sousa, Kilian Trillet, Mike Maillasson, Isabelle Leray, Yannick Jacques, Johann Dion, Isabelle Barbieux, Marie Frutoso, Adèle Laurent, Jean-Yves Le Questel, Erwan Mortier. IL-15Rα membrane-anchorage either in cis or in trans is required for stabilization of IL-15 and optimal signaling. Journal of Cell Science (2019). inserm-02345095

EQUIPE 2

Vivien Hebert, Claire Boulard, Estelle Houivet, Sophie Duvert Lehembre, Luca Borradori, Rocco Della Torre, Claudio Feliciani, Luca Fania, Giovanna Zambruno, Diana Camaioni, Biago Didona, Branka Marinovic, Enno Schmidt, Nina Schumacher, Christian Hünefeld, Stefan Schanz, Johannes Steffen Kern, Silke Hofmann, Anne Charlotte Bouyeure, Catherine Picard-Dahan, Catherine Prost-Squarcioni, Frédéric Caux, Marina Alexandre, Saskia Ingen-Housz-Oro, Martine Bagot, Emmanuel Tancrede-Bohin, Jean David Bouaziz, Nathalie Franck, Pierre Vabres, Bruno Labeille, Marie Richard, Emmanuel Delaporte, Alain Dupuy, Michel D’Incan, Gaelle Quéreux, François Skowro, Carle Paul, Cristina Bulai Livideanu, Marie Beylot-Barry, Marie Sylvie Doutre, Martine Avenel-Audran, Christophe Bédane, Philippe Bernard, Laurent Machet, Hervé Maillard, Denis Jullien, Sebastien Debarbieux, Bruno Sassolas, Laurent Misery, Claire Abasq, Olivier Dereure, Philippe Lagoutte, Vincent Ferranti, Victoria Werth, Dedee Murrell, Michael Hertl, Jacques Benichou, Pascal Joly, Michel D’Incan. Large International Validation of ABSIS and PDAI Pemphigus Severity Scores. Journal of Investigative Dermatology. (2019) 31-37. hal-01926791

Marthe Plaquevent, Florence Tétart, Laurence Fardet, Saskia Ingen-Housz-Oro, Laurence Valeyrie-Allanore, Philippe Bernard, Vivien Hebert, Aude Roussel, Martine Avenel-Audran, Guillaume Chaby, Michel D’Incan, Marie-Christine Ferrier-Le-Bouedec, Sophie Duvert-Lehembre, Catherine Picard-Dahan, Géraldine Jeudy, Evelyne Collet, Bruno Labeille, Cécile Morice, Marie-Aleth Richard, Isabelle Bourgault-Villada, Noémie Litrowski, Corina Bara, Emmanuel Mahé, Catherine Prost-Squarcioni, Marina Alexandre, Gaëlle Quéreux, Claire Bernier, Angèle Soria, Domitille Thomas-Beaulieu, Christine Pauwels, Olivier Dereure, Jacques Benichou, Pascal Joly. Higher Frequency of Dipeptidyl Peptidase-4 Inhibitor Intake in Bullous Pemphigoid Patients than in the French General Population. Journal of Investigative Dermatology. (2019) 835-841. hal-02090290

Lucie Peuvrel, Barbara Bregeon, Mélanie Saint-Jean, Gaëlle Quereux, Cécile Frénard, Amir Khammari, Annie Wdowik, Brigitte Dréno. First case of trastuzumab emtansine-associated hemorrhagic telangiectasias treated with propranolol. Dermatologic Therapy. (2019) e12756. inserm-02099553

Marie-Ange Dagnelie, Amir Khammari, Brigitte Dréno, Stéphane Corvec. Assessment of seven protocols to prepare Cutibacterium acnes bacterial lysates to measure its immunogenic potential and review of the literature. Anaerobe. (2019) 75-81. inserm-02117150

Alexandra Poinas, Pierre Perrot, Judith Lorant, Olivier Nerrière, Jean-Michel Nguyen, Soraya Saïagh, Cécile Frenard, Audrey Leduc, Olivier Malard, Florent Espitalier, Franck Duteille, Anne Chiffoleau, Florence Vrignaud, Amir Khammari, Brigitte Dreno. CICAFAST: comparison of a biological dressing composed of fetal fibroblasts and keratinocytes on a split-thickness skin graft donor site versus a traditional dressing: a randomized controlled trial. Trials (2019) inserm-02340860

S. Bocquet-Trémoureux, S. Corvec, A. Khammari, M.-A Dagnelie, A Boisrobert, B. Dréno. Acne fulminans and Cutibacterium acnes phylotypes. Journal of the European Academy of Dermatology and Venereology (2019). inserm-02474581

EQUIPE 3

Catherine Rabu, Laurie Rangan, Laetitia Florenceau, Agnès Fortun, Maud Charpentier, Emilie Dupré, Léa Paolini, Céline Beauvillain, Estelle Dupel, Jean-Baptiste Latouche, Olivier Adotévi, Nathalie Labarrière, François Lang. Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells. OncoImmunology. (2019) e1560919-2. inserm-01991877

Juliette Eugène, Nicolas Jouand, Kathleen Ducoin, Delphine Dansette, Romain Oger, Cécile Deleine, Edouard Leveque, Guillaume Meurette, Juliette Podevin, Tamara Matysiak, Jaafar Bennouna, Stéphane Bézieau, Christelle Volteau, Wassila El Alami Thomas, Jérôme Chetritt, Olivier Kerdraon, Pierre Fourquier, Emilie Thibaudeau, Frédéric Dumont, Jean-François Mosnier, Claire Toquet, Anne Jarry, Nadine Gervois, Céline Bossard. The inhibitory receptor CD94/NKG2A on CD8 + tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression. Modern Pathology. (2019) Epub ahead of print. inserm-02281341

Mahtab Samimi, Houssem Benlalam, Pascal Aumond, Pauline Gaboriaud, Delphine Fradin, Thibault Kervarrec, Laetitia Florenceau, Virginie Vignard, Astrid Blom, Antoine Touzé, Nadine Gervois, Nathalie Labarrière. Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma. Cellular Immunology (2019) 103961 inserm-02284748

Eva Ott, Linda Bilonda, Delphine Dansette, Cécile Deleine, Emilie Duchalais, Juliette Podevin, Christelle Volteau, Jaafar Bennouna, Yann Touchefeu, Pierre Fourquier, Wassila El Alami Thomas, Jérome Chetritt, Stéphane Bezieau, Marc Denis, Claire Toquet, Jean-François Mosnier, Anne Jarry, Céline Bossard. The density of Tbet+ tumor-infiltrating T lymphocytes reflects an effective and druggable preexisting adaptive antitumor immune response in colorectal cancer, irrespective of the microsatellite status. OncoImmunology. (2019) e1562834. inserm-02100125

EQUIPE 4

Philippe Bertrand, Christophe Blanquart, Valérie Héroguez. The ROMP: A Powerful Approach to Synthesize Novel pH-Sensitive Nanoparticles for Tumor Therapy. Biomolecules. (2019) 60. inserm-02055136

Jean-François Fonteneau, Eric Quemeneur. Oncolytic Immunovirotherapy: An Emerging Strategy for Cancer Treatment. Immunité & Cancer. (2019) Epub ahead of print. inserm-02100092

Samuel Bouchet, Camille Linot, Dusan Ruzic, Danica Agbaba, Benoit Fouchaq, Joëlle Roche, Katarina Nikolic, Christophe Blanquart, Philippe Bertrand. Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling. ACS Medicinal Chemistry Letters. (2019) 863-868. inserm-02265954

Joanna Boucard, Tina Briolay, Thibaut Blondy, Mohammed Boujtita, Steven Nedellec, Philippe Hulin, Marc Greǵoire, Christophe Blanquart, Eleńa Ishow. Hybrid Azo-fluorophore Organic Nanoparticles as Emissive Turn-on Probes for Cellular Endocytosis. ACS Applied Materials & Interfaces. (2019). inserm-02281253

Pierre Autin, Christophe Blanquart, Delphine Fradin. Epigenetic Drugs for Cancer and microRNAs: A Focus on Histone Deacetylase Inhibitors. Cancers (2019) 1530. inserm-02315396

EQUIPE 5

Joudy Alameddine, Emmanuelle Godefroy, Loukas Papargyris, Guillaume Sarrabayrouse, Julie Tabiasco, Chantal Bridonneau, Karina Yazdanbakhsh, Harry Sokol, Frédéric Altare, Francine Jotereau. Faecalibacterium prausnitzii Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction. Frontiers in Immunology. (2019) 143. hal-02024916

Ignacio Caballero, Mickaël Riou, Océane Hacquin, Claire Chevaleyre, Céline barc, Jérémy Pezant, Anne Pinard, Julien Fassy, Roger Rezzonico, Bernard Mari, Nathalie Heuzé-Vourc’H, Bruno Pitard, Georges Vassaux. Tetrafunctional Block Copolymers Promote Lung Gene Transfer in Newborn Piglets. Molecular Therapy – Nucleic Acids. (2019) 186-193. inserm-02080870

Kevin Lindsay, Sushma Bhosle, Chiara Zurla, Jared Beyersdorf, Kenneth Rogers, Daryll Vanover, Peng Xiao, Mariluz Araínga, Lisa Shirreff, Bruno Pitard, Patrick Baumhof, Francois Villinger, Philip Santangelo. Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging. Nature Biomedical Engineering. (2019) Epub ahead of print. inserm-02089115

Samuel Golten, Allan Patinec, Katy Akoumany, Jézabel Rocher, Jérôme Graton, Denis Jacquemin, Jean-Yves Le Questel, Arnaud Tessier, Jacques Lebreton, Virginie Blot, Muriel Pipelier, Jean-Yves Douillard, Jacques Le Pendu, Bruno Linclau, Didier Dubreuil. 3,4-Dideoxy-3,3,4,4-tetrafluoro-and 4-OH 1 Epimeric 3-Deoxy-3,3-difluoro-α-GalCer 2 Analogues: Synthesis and Biological Evaluation 3 on Human iNKT Cells Stimulation. European Journal of Medicinal Chemistry. (2019). inserm-02140266

Allan Patinec, Jézabel Rocher, Mickael Vourc’h, Antoine Roquilly, Karim Asehnoune, Jacques Le Pendu. Alterations of the iNKT cell compartment in brain-injured patients. Critical Care. (2019) 234. inserm-02168152

Thibault Colombani, Thomas Haudebourg, Marion Decossas, Olivier Lambert, Grâce Ada Da Silva, Frederic Altare, Bruno Pitard. Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation. Advanced Science. (2019) 1900288. inserm-02281244

Diane Beuzelin, Bruno Pitard, Bertrand Kaeffer. Oral Delivery of miRNA With Lipidic Aminoglycoside Derivatives in the Breastfed Rat. Frontiers in Physiology. (2019) NN. inserm-02281357

Tibor Farkas, Kui Yang, Jacques Le Pendu, Joel Baines, Rhonda Cardin. The Coxsackie Virus and Adenovirus Receptor (Car) is a Required Host Factor for Recovirus Infection : a Putative Enteric Calicivirus Receptor. Journal of Virology (2019) inserm-02289288

Bruno Pitard. Nanotaxi® pour les vaccins ARN et ADN. Médecine/Sciences (2019) 749-751. inserm-02315389

Jacques Le Pendu, Nathalie Ruvoën-Clouet. Fondness for sugars of enteric viruses confronts them with human glycans genetic diversity. Human Genetics (A paraître). inserm-02383993

EQUIPE 6

René Rozenbaum, Linzhu Su, Anita Umerska, Matthieu Eveillard, Joakim Håkansson, Margit Mahlapuu, Fan Huang, Jianfeng Liu, Zhenkun Zhang, Linqi Shi, Henny van der Mei, Henk Busscher, Prashant Sharma. Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in vivo. Journal of Controlled Release. (2019) 73-83. inserm-01959821

Jérémie Babonneau, Dimitri Bréard, Marie-Line Reynaert, Estelle Marion, David Guilet, Jean-Paul Saint André, Anne Croue, Priscille Brodin, Pascal Richomme, Laurent Marsollier. Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters. Frontiers in Pharmacology. (2019) Epub ahead of print. inserm-02100552

Diane Sanderink, Viviane Cassisa, Rachel Chenouard, Rafael Mahieu, Marie Kempf, Vincent Dubée, Matthieu Eveillard. Colistin–glycopeptide combinations against multidrug-resistant Acinetobacter baumannii in a mouse model of pneumonia. Future Microbiology. (2019) 581-586. inserm-02167761

Horace Degnonvi, Sebastien Fleuret, Clément Coudereau, Ronald Gnimavo, Sigrid Giffon, Edouard Yeramian, Roch Johnson, Estelle Marion. Effect of well drilling on Buruli ulcer incidence in Benin: a case-control, quantitative survey. Lancet Planetary Health. (2019). inserm-02284585

Marie-Line Reynaert, Denis Dupoiron, Edouard Yeramian, Laurent Marsollier, Priscille Brodin. Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls. Toxins. (2019) 516. inserm-02284632

M. Eveillard, C. Lemarié, C. Legeay, C. Ramont, L. Onillon, M. Corre, S. Lasocki. Contamination of sink drains with carbapenemase-producing Enterobacteriaceae in intensive care units: a concern but don’t worry so much!. Journal of Hospital Infection (2019) 30321-4. inserm-02298328

C. Lemarié, C. Legeay, S. Lasocki, R. Mahieu, A. Kouatchet, L. Bahier, L. Onillon, M. Corre, M. Kempf, M. Eveillard. Extended-spectrum β-lactamase Enterobacteriaceae (ESBLE) in intensive care units: strong correlation with the ESBLE colonization pressure in patients but not same species. Journal of Hospital Infection (2019). inserm-02298265

Carole Lemarié, Clément Legeay, Achille Kouatchet, Rafael Mahieu, Sigismond Lasocki, Pamela Holecska, Laura Onillon, Maxime Corre, Marie Kempf, Matthieu Eveillard. High prevalence of contamination of sink drains with carbapenemase-producing Enterobacteriaceae in 4 intensive care units apart from any epidemic context. American Journal of Infection Control (2019). inserm-02298350

EQUIPE 7

Cindy Staerck, Julie Tabiasco, Charlotte Godon, Yves Delneste, Jean-Philippe Bouchara, Maxime Fleury. Transcriptional profiling of Scedosporium apiospermum enzymatic antioxidant gene battery unravels the involvement of thioredoxin reductases against chemical and phagocytic cells oxidative stress. Medical Mycology. (2019) 363-373. inserm-01814253

Laurane Cottin, Jeremie Riou, Françoise Boyer, Anne Bouvier, Alain Zannetti, Anaïse Blouet, Matgorzata Truchan-Graczyk, Rebecca Jouanneau-Courville, Annaelle Beucher, Bénédicte Ribourtout, Corentin Orvain, Mathilde Hunault-Berger, Odile Blanchet, Valérie Ugo, Damien Luque Paz. WT1 gene is overexpressed in myeloproliferative neoplasms, especially in myelofibrosis. Blood Cells, Molecules and Diseases. (2019) 35-40. inserm-01992425

Vincent Larochette, Charline Miot, Caroline Poli, Elodie Beaumont, Philippe Roingeard, Helmut Fickenscher, Pascale Jeannin, Yves Delneste. IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense. Frontiers in Immunology. (2019). inserm-02055151

Anne-Sophie Garnier, Martin Planchais, Jérémie Riou, Clément Jacquemin, Laurence Ordonez, Jean-Paul Saint-André, Anne Croue, Abdelhadi Saoudi, Yves Delneste, Anne Devys, Isabelle Boutin, Jean-François Subra, Agnès Duveau, Jean-François Augusto. Pre-transplant CD45RC expression on blood T cells differentiates patients with cancer and rejection after kidney transplantation. PLoS ONE. (2019) e0214321. inserm-02100184

Annaelle Beucher, Mammoun Dib, Corentin Orvain, Anne Bouvier, Rebecca Jouanneau‐Courville, Irène Dobo, Laurane Cottin, Philippe Guardiola, Marie‐Christine Rousselet, Odile Blanchet, Mathilde Hunault, Valérie Ugo, Damien Luque Paz. Next generation sequencing redefines a triple negative essential thrombocythaemia as double‐positive with rare mutations on JAK 2 V617 and MPL W515 hotspots. British Journal of Haematology. (2019). inserm-02165208

Damien Luque Paz, Olivier Mansier, Jérémie Riou, Carole Conejero, Lydia Roy, Célia Belkhodja, Valérie Ugo, Stéphane Giraudier. Positive impact of molecular analysis on prognostic scores in essential thrombocythemia: a single center prospective cohort experience. Haematologica. (2019) e134-e137. inserm-02167856

Marie Lemerle, Anne-Sophie Garnier, Martin Planchais, Benoit Brilland, Yves Delneste, Jean-François Subra, Odile Blanchet, Simon Blanchard, Anne Croué, Agnès Duveau, Jean-François Augusto. CD45RC Expression of Circulating CD8+ T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients. Journal of Clinical Medicine Research. (2019) 1147. inserm-02265791

Fanny Guibert, Anne-Sophie Garnier, Samuel Wacrenier, Giorgina Piccoli, Assia Djema, Renaud Gansey, Julien Demiselle, Benoit Brilland, Maud Cousin, Virginie Besson, Agnès Duveau, Khuzama Nasser, Jean-Philippe Coindre, Anne Croue, Jean-Paul Saint-André, Alain Chevailler, Jean-François Subra, Jean-François Augusto. Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry. Journal of Clinical Medicine. (2019) pii: E1218. inserm-02281250

EQUIPE 8

Appala Venkata Ramana Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, Anagani Kanaka Durga Bhavani, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Paul Mosset, René Grée, Nicolas Levoin. Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells. European Journal of Medicinal Chemistry. 334-347. hal-01937242

Elie Dagher, Jérôme Abadie, Delphine Loussouarn, Dominique Fanuel, Mario Campone, Frédérique Nguyen. Bcl-2 expression and prognostic significance in feline invasive mammary carcinomas: a retrospective observational study. BMC Veterinary Research. 25. inserm-01991065

Kevin Louault, Thomas Bonneaud, Céline Séveno, Patricia Gomez-Bougie, Frédérique Nguyen, Fabien Gautier, Nathalie Bourgeois, Delphine Loussouarn, Olivier Kerdraon, Sophie Barillé-Nion, Pascal Jézéquel, Mario Campone, Martine Amiot, Philippe Juin, Frédérique Souazé. Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers. Oncogene. Epub ahead of print. inserm-01991165

Jordan Guillon, Coralie Petit, Marie Moreau, Bertrand Toutain, Cécile Henry, Henry Roché, Nathalie Bonichon-Lamichhane, Jean Salmon, Jérôme Lemonnier, Mario Campone, Veronique Verriele, Eric Lelièvre, Catherine Guette, Olivier Coqueret. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death and Disease. inserm-02055140

Pascal Jézéquel, Olivier Kerdraon, Hubert Hondermarck, Catherine Guérin-Charbonnel, Hamza Lasla, Wilfried Gouraud, Jean-Luc Canon, Andrea Gombos, Florence Dalenc, Suzette Delaloge, Jérôme Lemonnier, Delphine Loussouarn, Veronique Verriele, Mario Campone. Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications. Breast Cancer Research. 65. inserm-02140196

Elie Dagher, Jérôme Abadie, Delphine Loussouarn, Mario Campone, Frédérique Nguyen. Feline Invasive Mammary Carcinomas: Prognostic Value of Histological Grading. Veterinary Pathology. inserm-02167919

Isabelle Valo, Pédro Raro, Alice Boissard, Amine Maarouf, Pascal Jézéquel, Veronique Verriele, Mario Campone, Olivier Coqueret, Catherine Guette. OLFM4 Expression in Ductal Carcinoma In Situ and in Invasive Breast Cancer Cohorts by a SWATH‐Based Proteomic Approach. Proteomics. e1800446. inserm-02281345

Pascal Jézéquel, Catherine Guette, Hamza Lasla, Wilfried Gouraud, Alice Boissard, Catherine Guérin-Charbonnel, Mario Campone. iTRAQ‐Based Quantitative Proteomic Analysis Strengthens Transcriptomic Subtyping of Triple‐Negative Breast Cancer Tumors. Proteomics. 1800484. inserm-02281393

Florian Chocteau, Jérôme Abadie, Delphine Loussouarn, Frédérique Nguyen. Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 1: Canine Mammary Carcinomas. Frontiers in Veterinary Science (2019). inserm-02383821

Florian Chocteau, Marie-Mélanie Boulay, Fanny Besnard, Germain Valeau, Delphine Loussouarn, Frédérique Nguyen. Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 2: Feline Mammary Carcinomas. Frontiers in Veterinary Science (2019). inserm-02383102

Pierre Avril, Luciano Vidal, Sophie Barille-Nion, Louis-Romée Le Nail, Françoise Rédini, Pierre Layrolle, Michelle Pinault, Stéphane Chevalier, Pierre Perrot, Valérie Trichet. Epinephrine Infiltration of Adipose Tissue Impacts MCF7 Breast Cancer Cells and Total Lipid Content. International Journal of Molecular Sciences Article (2019). inserm-02383856

EQUIPE 9

Kristina Schiavone, Delphine Garnier, Marie Françoise Heymann, Dominique Heymann. The heterogeneity of osteosarcoma: the role played by cancer stem cells. Advances in Experimental Medicine and Biology. (2019). hal-02078118

Fabrice Chatonnet, Amandine Pignarre, Aurelien Serandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José Martin-Subero, Jerome Moreaux, Thierry Fest, Gilles Salbert. The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation. Haematologica. (2019) haematol.2019.222133. hal-02165596

Marta Tellez-Gabriel, Marie-Françoise Heymann, Dominique Heymann. Circulating tumor cells as a tool for assessing tumor heterogeneity. Theranostics. (2019) Epub ahead of print. inserm-02110266

Julien Fleurence, Meriem Bahri, Sophie Fougeray, Sébastien Faraj, Sarah Vermeulen, Émilie Pinault, Fanny Geraldo, Lisa Oliver, Joëlle Véziers, Pierre Marquet, Marion Rabé, Catherine Gratas, François Vallette, Claire Pecqueur, François Paris, Stéphane Birklé. Impairing Temozolomide Resistance Driven by Glioma Stem-like Cells with adjuvant Immunotherapy Targeting O-acetyl GD2 Ganglioside. International Journal of Cancer. (2019) Epub ahead of print. inserm-02168202

Delphine Garnier, Ophélie Renoult, Marie-Clotilde Alves-Guerra, François Paris, Claire Pecqueur. Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target. Frontiers in Oncology. (2019) 118. inserm-02240417

Vincent Potiron, Karen Clément-Colmou, Emmanuel Jouglar, Manon Pietri, Sophie Chiavassa, Grégory Delpon, François Paris, Stéphane Supiot. Tumor vasculature remodeling by radiation therapy increases doxorubicin distribution and efficacy. Cancer Letters. (2019) 1-9. inserm-02265795

Stéphane Supiot, Caroline Rousseau, Mélanie Dore, Catherine Cheze-Le-Rest, Christine Kandel-Aznar, Vincent Potiron, Stéphane Guerif, François Paris, Ludovic Ferrer, Loïc Campion, Philippe Meingan, Grégory Delpon, Mathieu Hatt, Dimitris VISVIKIS. Reoxygenation during radiotherapy in intermediate-risk prostate cancer. Radiotherapy and Oncology. (2019) 16-19. inserm-02265798

Aurélie Ginisty, Lisa Oliver, Patricia Arnault, François Vallette, Omar Benzakour, Valérie Coronas. The vitamin K-dependent factor, protein S, regulates brain neural stem cell migration and phagocytic activities towards glioma cells. European Journal of Pharmacology. (2019) 30-39. inserm-02265838

Manon Duforestel, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Josephine Briand, Christophe Olivier, Jean-Sébastien Frenel, François Vallette, Sophie Lelièvre, Pierre-François Cartron. Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner. Frontiers in Genetics (2019). inserm-02309615

Josephine Briand, Marie-Pierre Joalland, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Christophe Olivier, François Vallette, Sylvain Perruche, Pierre-Francois Cartron. Diuron modulates the DNA methylation status of the ILT7 and TRAIL/TNFSF10 genes and decreases the killing activity of plasmacytoid dendritic cells. Environmental Sciences Europe (2019). 31-1. inserm-02309623

Simon Valès, Gregory Bacola, Mandy Biraud, Mélissa Touvron, Anne Bessard, Fanny Geraldo, Kelsie Dougherty, Shaian Lashani, Céline Bossard, Mathurin Flamant, Emilie Duchalais, Séverine Marionneau-Lambot, Thibauld Oullier, Lisa Oliver, Michel Neunlist, François Vallette, Laurianne van Landeghem. Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis. EBioMedicine (2019). inserm-02337834

EQUIPE 10

Bastien Jamet, Clément Bailly, Thomas Carlier, Cyrille Touzeau, Cristina Nanni, Elena Zamagni, Louisa Barré, Anne-Victoire Michaud, Michel Chérel, Philippe Moreau, Caroline Bodet-Milin, Françoise Kraeber-Bodéré. Interest of PET Imaging in Multiple Myeloma. Frontiers in Medicine. (2019) 69. hal-02088227

Benoit Tessoulin, Antonin Papin, Patricia Gomez-Bougie, Céline Bellanger, Martine Amiot, Catherine Pellat-Deceunynck, David Chiron. BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker. Frontiers in Oncology. (2019) 645. hal-02128662

Bastien Jamet, Clément Bailly, Thomas Carlier, Lucie Planche, Cyrille Touzeau, Françoise Kraeber-Bodéré, Philippe Moreau, Caroline Bodet-Milin. Added prognostic value of FDG-PET/CT in relapsing multiple myeloma patients. Leukemia & lymphoma. (2019) 222-225. inserm-01823037

Agathe Dubuisson, Cécile Favreau, Eric Fourmaux, Sabrina Lareure, Rafael Rodrigues-Saraiva, Catherine Pellat-Deceunynck, Said El Alaoui, Olivier Micheau. Generation and characterization of novel anti-DR4 and anti-DR5 antibodies developed by genetic immunization. Cell Death and Disease. (2019) Epub ahead of print. inserm-02006230

Benoit Tessoulin, Géraldine Descamps, Christelle Dousset, Martine Amiot, Catherine Pellat-Deceunynck. Targeting Oxidative Stress With Auranofin or Prima-1Met to Circumvent p53 or Bax/Bak Deficiency in Myeloma Cells. Frontiers in Oncology. (2019). inserm-02055153

David Chiron. Three targets in 1 shot against ibrutinib resistance. Blood. (2019). inserm-02080892

Antonin Papin, Benoit Tessoulin, Céline Bellanger, Anne Moreau, Yannick Le Bris, Hervé Maisonneuve, Philippe Moreau, Cyrille Touzeau, Martine Amiot, Catherine Pellat-Deceunynck, Steven Le Gouill, David Chiron. CSF1R and BTK inhibitions as novel strategies to disrupt the dialogue between mantle cell lymphoma and macrophages. Leukemia. (2019) Epub ahead of print. inserm-02081007

Clément Bailly, Thomas Carlier, Cyrille Touzeau, Nicolas Arlicot, Françoise Kraeber-Bodéré, Steven Le Gouill, Caroline Bodet-Milin. Interest of FDG-PET in the Management of Mantle Cell Lymphoma. Frontiers in Medicine. (2019) Epub ahead of print. inserm-02100231

Clément Bailly, Thomas Carlier, Bastien Jamet, Cyrille Touzeau, Philippe Moreau, Françoise Kraeber-Bodéré, Caroline Bodet-Milin. 18F-FDG PET/CT in multiple myeloma: critical insights and future directions. European Journal of Nuclear Medicine and Molecular Imaging. (2019) 1048-1050. inserm-02100540

Ludivine Morvan, Diana Mateus, Clément Bailly, Bastien Jamet, Caroline Bodet-Milin, Philippe Moreau, Cyrille Touzeau, Françoise Kraeber-Bodéré, Thomas Carlier. Prédiction de la progression chez des patients atteints de myélome multiple par « Random Survival Forest ».[Poster]. (2019). inserm-02100680

Aimeric Dabin, Thomas Goronflot, Benoît Tessoulin, David Chiron, Anne Monlien, Steven Le Gouill, Pierre-Antoine Gourraud, Matilde Karakachoff. Bridging Refract-Lyma and CHUN Clinical Data Warehouse: from a research cohort to a regional electronic medical record system and back. [Poster] (2019). inserm-02163132

Jonathan Harnoss, Adrien Le Thomas, Anna Shemorry, Scot Marsters, David Lawrence, Min Lu, Yung-Chia Chen, Jing Qing, Klara Totpal, David Kan, Ehud Segal, Mark Merchant, Mike Reichelt, Heidi Wallweber, Weiru Wang, Kevin Clark, Susan Kaufman, Maureen Beresini, Steven Laing, Wendy Sandoval, Maria Lorenzo, Jiansheng Wu, Justin Ly, Tom De Bruyn, Amy Heidersbach, Benjamin Haley, Alvin Gogineni, Robby Weimer, Dong Lee, Marie-Gabrielle Braun, Joachim Rudolph, Michael VanWyngarden, Daniel Sherbenou, Patricia Gomez-Bougie, Martine Amiot, Diego Acosta-Alvear, Peter Walter, Avi Ashkenazi. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America. (2019) 201906999. inserm-02265831

Clément Bailly, Thomas Carlier, Alina Berriolo-Riedinger, Olivier Casasnovas, Emmanuel Gyan, Michel Meignan, Anne Moreau, Barbara Burroni, Loïc Djaileb, Rémy Gressin, Anne Devillers, Thierry Lamy, Catherine Thieblemont, Olivier Hermine, Françoise Kraeber-Bodéré, Steven Le Gouill, Caroline Bodet-Milin. Prognostic value of FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project. Haematologica. (2019) Epub ahead of print. inserm-02266351

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine. (2019) 85-87. inserm-02266372

Tiphaine Douanne, Gwennan André-Grégoire, Kilian Trillet, An Thys, Antonin Papin, Magalie Feyeux, Philippe Hulin, David Chiron, Julie Gavard, Nicolas Bidère. Pannexin‐1 limits the production of proinflammatory cytokines during necroptosis. EMBO Reports. (2019) e47840. inserm-02281304

Lina Benaniba, Benoit Tessoulin, Sabrina Trudel, Catherine Pellat-Deceunynck, Martine Amiot, Stephane Minvielle, Pierre Gourraud, Sophie de Visme, Hervé Maisonneuve, Anne Lok, Steven Le Gouill, Philippe Moreau, Cyrille Touzeau. The MYRACLE protocol study: a multicentric observational prospective cohort study of patients with multiple myeloma. BMC Cancer (2019) 19-1. inserm-02290127

EQUIPE 11

Basile Henriot, Emmanuel Rouger, Chloé Rousseau, Martine Escoffre, Martine Sébillot, Claude Bendavid, Stephane Minvielle, Hervé Avet-Loiseau, Olivier Decaux, Caroline Moreau. Prognostic value of involved/uninvolved free light chain ratio determined by Freelite and N Latex FLC assays for identification of high-risk smoldering myeloma patients. Clinical Chemistry and Laboratory Medicine. (2019). hal-02120882

Ludivine Morvan, Thomas Carlier, Bastien Jamet, Clément Bailly, Caroline Bodet-Milin, Philippe Moreau, Francoise Kraeber-Bodere, Diana Mateus. Leveraging RSF and PET images for prognosis of Multiple Myeloma at diagnosis. International Journal of Computer Assisted Radiology and Surgery. (2019). hal-02172435

Matthieu Barbaud, Mathieu Frindel, Ludovic Ferrer, Maëlle Le Thiec, Daniela Rusu, Aurore Rauscher, Bruno Maucherat, Pierre Baumgartner, Vincent Fleury, Mathilde Colombié, Agnes Thierry‐Morel, Françoise Kraeber‐Bodéré, Loïc Campion, Caroline Rousseau. 68Ga‐PSMA‐11 PET‐CT study in prostate cancer patients with biochemical recurrence and non‐contributive 18F‐Choline PET‐CT: Impact on therapeutic decision‐making and biomarker changes. Prostate. (2019) 454-461. inserm-01980821

Caroline Bodet-Milin, Clément Bailly, Yann Touchefeu, Eric Frampas, Mickaël Bourgeois, Aurore Rauscher, Franck Lacœuille, Delphine Drui, Nicolas Arlicot, David Goldenberg, Alain Faivre-Chauvet, Jacques Barbet, Caroline Rousseau, Francoise Kraeber-Bodere. Clinical Results in Medullary Thyroid Carcinoma Suggest High Potential of Pretargeted Immuno-PET for Tumor Imaging and Theranostic Approaches. Frontiers in Medicine. (2019). inserm-02167740

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine. (2019) 85-87. inserm-02266372

Francesco Maura, Niccolo Bolli, Nicos Angelopoulos, Kevin Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodríguez-Martín, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Jose Tubio, David Wedge, Moritz Gerstung, Hervé Avet-Loiseau, Nikhil Munshi, Peter Campbell. Genomic landscape and chronological reconstruction of driver events in multiple myeloma. Nature Communications (2019) 10-1. inserm-02290176

Anil Samur, Stephane Minvielle, Masood Shammas, Mariateresa Fulciniti, Florence Magrangeas, Paul Richardson, Philippe Moreau, Michel Attal, Kenneth Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil Munshi, Mehmet Samur. Deciphering the chronology of copy number alterations in Multiple Myeloma. Blood Cancer Journal (2019) 9-4. inserm-02290251

B. Maucherat, A. Leduc-Pennec, N. Fleury, Ludovic Ferrer, E. Bourbouloux, H. Simon, M. Le Thiec, D. Rusu, V. Fleury, M. Colombie, A. Morel, Françoise Kraeber-Bodéré, Loïc Campion, Caroline Rousseau. First results of molecular imaging (FDG and FES) in prospective study for selecting second line hormonotherapy in estrogen receptors positive metastatic breast cancer patients. European Journal of Nuclear Medicine and Molecular Imaging (2019). inserm-02337440

EQUIPE 12

Coralie Petit, Jordan Guillon, Bertrand Toutain, Alice Boissard, Anne Patsouris, Eric Lelievre, Catherine Guette, Olivier Coqueret. Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response. Proteomics. (2019) inserm-02140239

Olivier Pluquet, Corinne Abbadie, Olivier Coqueret. Connecting cancer relapse with senescence. Cancer Letters. (2019). inserm-02281280

Jordan Guillon, Coralie Petit, Bertrand Toutain, Catherine Guette, Eric Lelievre, Olivier Coqueret. Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity. Cell Cycle. (2019). inserm-02281354

EQUIPE 13

Matthieu Moreau. Introduction à l’imagerie par Tomographie d’Émission de Positons : définitions, approches de reconstruction et initiation aux isotopes complexes.. [Pré-publication]. (2019) hal-01660503

Clément Bailly, Sébastien Gouard, François Guérard, Benjamin Chalopin, Thomas Carlier, Alain Faivre-Chauvet, Patricia Remaud-Le Saec, Mickaël Bourgeois, Nicolas Chouin, Latifa Rbah-Vidal, Raphaël Tripier, Ferid Haddad, Françoise Kraeber-Bodéré, Caroline Bodet-Milin, Michel Chérel. What is the Best Radionuclide for Immuno-PET of Multiple Myeloma? A Comparison Study Between 89Zr- and 64Cu-Labeled Anti-CD138 in a Preclinical Syngeneic Model. International Journal of Molecular Sciences. (2019) 2564. hal-02141555

Michael Gérard, Aurélien Corroyer-Dulmont, Paul Lesueur, Solène Collet, Michel Chérel, Mickaël Bourgeois, Dinu Stefan, Elaine Johanna Limkin, Cécile Perrio, Jean-Sébastien Guillamo, Bernard Dubray, Myriam Bernaudin, Juliette Thariat, Samuel Valable. Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma. Frontiers in Medicine. (2019). hal-02153761

Clément Bailly, Aurélien Vidal, Coralie Bonnemaire, Françoise Kraeber-Bodéré, Michel Chérel, Amandine Pallardy, Caroline Rousseau, Emmanuel Garcion, Franck Lacoeuille, François Hindré, Samuel Valable, Myriam Bernaudin, Caroline Bodet-Milin, Mickael Bourgeois. Potential for nuclear medicine therapy for glioblastoma treatment. Frontiers in Pharmacology. (2019). hal-02163322

Laurent Navarro, Marion Berdal, Michel Chérel, Frédéric Pecorari, Jean-François Gestin, François Guérard. Prosthetic groups for radioiodination and astatination of peptides and proteins: a comparative study of five potential bioorthogonal labeling strategies. Bioorganic and Medicinal Chemistry. (2019) 167-174. inserm-01939636

Maëlle Le Thiec, Daniela Rusu, Vincent Fleury, Françoise Kraeber-Bodéré, Caroline Rousseau. 68Ga-PSMA PET/CT Urachus Metastases in Recurrent Prostate Cancer With Very Low PSA Level. Clinical Nuclear Medicine. (2019) 40-41. inserm-01991118

Charbel Koumeir, Viviana De Nadal, Roberto Cherubini, Michel Chérel, Eric Garrido, Sébastien Gouard, Arnaud Guertin, Ferid Haddad, Vincent Métivier, Nathalie Michel, Freddy Poirier, Noël Servagent, Thomas Sounalet, Nicolas Varmenot. The Radiobiological platform at Arronax. Radiation Protection Dosimetry. (2019) Epub ahead of print. inserm-02023308

Ghislaine Béhar, Axelle Renodon-Cornière, Stanimir Kambarev, Petar Vukojicic, Nathalie Caroff, Stéphane Corvec, Barbara Mouratou, Frédéric Pecorari. Whole-bacterium ribosome display selection for isolation of highly specific anti-Staphyloccocus aureus Affitins for detection- and capture- based biomedical applications. Biotechnology and Bioengineering. (2019) Epub ahead of print. inserm-02140227

Nicolas Lepareur, Franck Lacœuille, Christelle Bouvry, François Hindré, Emmanuel Garcion, Michel Chérel, Nicolas Noiret, Etienne Garin, F Russ Knapp Jr.. Rhenium-188 Labeled Radiopharmaceuticals: Current Clinical Applications in Oncology and Promising Perspectives. Frontiers in Medicine. (2019) 132. inserm-02167816

Petar Vukojicic, Ghislaine Behar, Maun H. Tawara, Marcos Fernandez-Villamarin, Frédéric Pecorari, Eduardo Fernandez-Megia, Barbara Mouratou. Multivalent Affidendrons with High Affinity and Specificity toward Staphylococcus aureus as Versatile Tools for Modulating Multicellular Behaviors. ACS Applied Materials & Interfaces. (2019) 21391-21398. inserm-02167902

Thomas Chabot, Alain Defontaine, Damien Marquis, Axelle Renodon-Cornière, Emmanuelle Courtois, Fabrice Fleury, Yvonnick Cheraud. New Phosphorylation Sites of Rad51 by c-Met Modulates Presynaptic Filament Stability. Cancers. (2019) 413. inserm-02168094

Nadia Benabdallah, Catherine Saï-Maurel, Didier Franck, Claire de Labriolle-Vaylet, Aurélie Desbrée, Michel Chérel, Sébastien Gouard, Jean-Marc Bertho, Dimitri Kereselidze, Jérôme Donnard, Stéphanie Lerondel, Anne Chauchereau, Nicolas Chouin, Michel Bernardini. Optimization of Dosimetry in Alpha Therapy: Microlocalisation of 223Ra in Mouse Models of Metastasis from Prostate Cancer and Renal Cell Carcinoma. Journal of Medical Imaging and Radiation Sciences. (2019) S10-S11. inserm-02178828

Anne-Sophie Navarro, Thomas Le Bihan, Patricia Le Saec, Nathalie le Bris, Clément Bailly, Catherine Sai-Morel, Mickaël Bourgeois, Michel Chérel, Raphaël Tripier, Alain Faivre-Chauvet. TE1PA as innovating chelator for 64Cu immuno-TEP imaging: a comparative in vivo study with DOTA/NOTA by conjugation on 9E7.4 mAb in a syngeneic multiple myeloma model. Bioconjugate Chemistry. (2019). inserm-02266369

Pierre Peterlin, Joëlle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Chérel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier. FLT3 ligand plasma levels have no impact on outcomes after allotransplant in acute leukemia. Cytokine. (2019) 85-87. inserm-02266372

Clément Bailly, Caroline Bodet-Milin, François Guérard, Nicolas Chouin, Joëlle Gaschet, Michel Chérel, François Davodeau, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré, Mickael Bourgeois. Radioimmunotherapy of Lymphomas. [In] Nuclear Medicine Therapy (2019). inserm-02309716

Clément Bailly, Caroline Bodet-Milin, Mickael Bourgeois, Sébastien Gouard, Catherine Ansquer, Matthieu Barbaud, Jean-Charles Sébille, Michel Chérel, Françoise Kraeber-Bodéré, Thomas Carlier. Exploring Tumor Heterogeneity Using PET Imaging: The Big Picture. Cancers (2019) 1282. inserm-02318425

Bastien Jamet, Clément Bailly, Thomas Carlier, Anne-Victoire Michaud, Cyrille Touzeau, Philippe Moreau, Caroline Bodet-Milin, Françoise Kraeber-Bodéré. FDG PET in Multiple Myeloma. [in] Molecular Imaging in Multiple Myeloma (2019) 27-38. inserm-02318406

Romain Lonceint, Françoise Bodéré, Bénédicte Geffroy. Risk Management Through an “Activity Contradictions” Lens: Exposure to Low Doses of Radiation in Nuclear Medicine. Frontiers in Medicine (2019) . inserm-02336947

Pauline Resnier, Elise Lepeltier, Anthea Emina, Natacha Galopin, Jérôme Bejaud, Stéphanie David, Caroline Ballet, Thierry Benvegnu, Frédéric Pécorari, Igor Chourpa, Jean-Pierre Benoit, Catherine Passirani. Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and in vivo biodistribution improvements. RSC Advances (2019) 27264-27278. inserm-02337070

Caroline Rousseau, A. Michaud, M. Barbaud, C. Morvant, B. Maucherat, M. Le Thiec, D. Rusu, A. Morel, V. Fleury, M. Colombie, A. Rauscher, Mathieu Frindel, P. Baumgartner, N. Fleury, Loïc Campion, Françoise Kraeber-Bodéré. 68Ga-PSMA-11 PET-CT study in prostate cancer patients with biochemical recurrence and non-contributive 18F-Choline PET-CT : impact on therapeutic decision-making and biomarker changes. European Journal of Nuclear Medicine and Molecular Imaging (2019). inserm-02337759

Nadia Benabdallah, Catherine Saï-Maurel, Didier Franck, Claire de Labriolle-Vaylet, Aurélie Desbrée, Michel Chérel, Sébastien Gouard, Jean-Marc Bertho, Mr Kereselidze, Jérôme Donnard, Stéphanie Lerondel, Anne Chauchereau, Nicolas Chouin, Mrs Michela Bernardini. Optimization of Dosimetry in Alpha Therapy : Microlocalisation of 223Ra in Mouse Models of Metastasis from Prostate Cancer and Renal Cell Carcinoma. Journal of Medical Imaging and Radiation Sciences (2019) S10. inserm-02340727

Marion Berdal, Laurent Navarro, Cyrille Alliot, Michel Chérel, Alain Faivre-Chauvet, Jean-François Gestin, François Guérard. Direct nucleophilic radioiodination and astatination of antibodies via pre-conjugated arylboronic acids. Journal of Labelled Compounds and Radiopharmaceuticals (2019) S314. inserm-02340736

Sébastien Bergeret, Judith Charbit, Catherine Ansquer, Géraldine Bera, Philippe Chanson, Charlotte Lussey-Lepoutre. Novel PET tracers: added value for endocrine disorders. Endocrine. International Journal of Basic and Clinical Endocrinology (2019) 14-30. hal-02336247

François Guérard, Laurent Navarro, Marion Berdal, Ferid Haddad, Michel Chérel, Jean-François Gestin. Advances in the Radiolabeling of Antibodies with Astatine-211 : Toward Simplified Procedures and Improved Radiochemical Yields. Journal of Medical Imaging and Radiation Sciences (2019) S29. inserm-02340810

Alexandre Lugat, Delphine Drui, Eric Mirallié, Françoise Kraeber-Bodéré, Catherine Ansquer. 18F-FDOPA PET Compared With 123I-Metaiodobenzylguanidine Scintigraphy and 18F-FDG PET in Secreting Sporadic Pheochromocytoma. Clinical Nuclear Medicine (2019) 738-740. inserm-02340819

Aurélia Roumesy, Sébastien Gouard, Laurent Navarro, Faustine Lelan, Ferid Haddad, François Guérard, Alain Faivre-Chauvet, Michel Chérel, Jean-Francois Gestin. Synthesis of precursors for 211At-labelling of anti-PSMA HuJ591 mAb and stability comparison after in vitro cellular internalization. Journal of Labelled Compounds and Radiopharmaceuticals (2019) S69. inserm-02340836

Emmanuelle Trébouet, Sahar Bannani, Matthieu Wargny, Christophe Leux, Cécile Caillard, Françoise Kraeber-Bodéré, Karine Renaudin, Lucy Chaillous, Eric Mirallié, Catherine Ansqueret. Mild sporadic primary hyperparathyroidism: high rate of multiglandular disease is associated with lower surgical cure rate. Langenbeck’s Archives of Surgery (2019) inserm-02340849

EQUIPE 14

C. Sosa Marrero, O. Acosta, M. Castro, A. Hernandez, N. Rioux-Leclercq, R. Mathieu, F. Paris, R. De Crevoisier. Sensitivity analysis of an in silico model of prostate tumour growth and response to radiotherapy. Radiotherapy and Oncology. (2019) S527-S528. hal-02177162

Tra-My Doan-Ngoc, Gaëlle Tilly, Sarah Bruneau, Alexandre Glemain, Sophie Brouard, Claire Pecqueur, Nicolas Degauque. Metabolic pathways regulate the migration of TEMRA CD8 to inflammatory site. [Poster] Focis. (2019). inserm-02158943

Esther Aguilar, Pauline Esteves, Tiphaine Sancerni, Veronique Lenoir, Thomas Aparicio, Frédéric Bouillaud, Renaud Dentin, Carina Prip-Buus, Daniel Ricquier, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra. UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses. Cell Reports (2019) 2306-2316.e5. inserm-02309113

EQUIPE 15

Andressa Duarte, Gwennan André-Grégoire, Kilian Trillet, An Thys, Nicolas Bidère, Alfredo Ribeiro-Silva, Julie Gavard. Inhibition of mTOR in head and neck cancer cells alters endothelial cell morphology in a paracrine fashion. Molecular Carcinogenesis. (2019) 161-168. inserm-01908781

Tiphaine Douanne, Gwennan André-Grégoire, Magalie Feyeux, Philippe Hulin, Julie Gavard, Nicolas Bidère. Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles. (2019). inserm-02055145

Tiphaine Douanne, Gwennan André-Grégoire, An Thys, Kilian Trillet, Julie Gavard, Nicolas Bidère. CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1. Cell Reports. (2019) 1657-1665. inserm-02128157

Anita Guequén, Patricia Zamorano, Francisco Córdova, Tania Koning, Angelo Torres, Pamela Ehrenfeld, Mauricio Boric, Flavio Salazar-Onfray, Julie Gavard, Walter Durán, Claudia Quezada, José Sarmiento, Fabiola Sánchez. Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells. Frontiers in Physiology. (2019). inserm-02281332

Kathryn Jacobs, Gwennan André-Grégoire, Clément Maghe, An Thys, Ying Li, Elizabeth Harford-Wright, Kilian Trillet, Tiphaine Douanne, Carolina Alves Nicolau, Jean-Sébastien Frenel, Nicolas Bidère, Julie Gavard. Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis. EMBO Journal (2019). inserm-02395350

EQUIPE 16

EQUIPE 17

Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Fréderic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valérie Rigau, Anne-Isabelle Bertozzi, David Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste. EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity. Brain Pathology. (2019). inserm-1812464

Hélène Lajous, Bénédicte Lelièvre, Elodie Vauleon, Philippe Lecomte, Emmanuel Garcion. Rethinking Alkylating(-Like) Agents for Solid Tumor Management. Trends in Pharmacological Sciences. (2019) 342-357. hal-02121104

Anne Clavreul, Gwénaëlle Soulard, Jean-Michel Lemée, Marion Rigot, Pascale Fabbro-Peray, Luc Bauchet, Dominique Figarella-Branger, Philippe Menei. The French glioblastoma biobank (FGB): a national clinicobiological database. Journal of Translational Medicine. (2019) 133. hal-02156158

Lila Autier, Anne Clavreul, Maximiliano Cacicedo, Florence Franconi, Laurence Sindji, Audrey Rousseau, Rodolphe Perrot, Claudia Montero-Menei, Guillermo Castro, Philippe Menei. A new glioblastoma cell trap for implantation after surgical resection. Acta Biomaterialia. (2019). inserm-01957962

Shubaash Anthiya, Audrey Griveau, Claire Loussouarn, Patrick Baril, Martin Garnett, Jean-Paul Issartel, Emmanuel Garcion. MicroRNA-based therapeutics and nanomedicine for brain tumour treatment. [Document de travail]. (2019). inserm-02178906

Imprimer