Liste des publications par équipe pour l'année 2016 - CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes Angers

PUBLICATIONS DE 2016

EQUIPE 1 EQUIPE 2 EQUIPE 3 EQUIPE 4 EQUIPE 5 EQUIPE 6 EQUIPE 7 EQUIPE 8 EQUIPE 9

EQUIPE 10 EQUIPE 11 EQUIPE 12 EQUIPE 13 EQUIPE 14 EQUIPE 15 EQUIPE 16

EQUIPE 1

Marc Bonneville, Zheng Chen, Julie Déchanet-Merville, Matthias Eberl, Jean-Jacques Fournié, Julie Jameson, Richard Lopez, Massimo Massaia, Bruno Silva-Santos. Chicago 2014 – 30 years of gamma delta T cells. Cellular Immunology (2016). inserm-01280762

Zsolt Sebestyen, Wouter Scheper, Anna Vyborova, Siyi Gu, Zuzana Rychnavska, Marleen Schiffler, Astrid Cleven, Coraline Chéneau, Martje Van Noorden, Cassie-Marie Peigné, Daniel Olive, Robert Jan Lebbink, Rimke Oostvogels, Tuna Mutis, Gerrit Jan Schuurhuis, Erin J. Adams, Emmanuel Scotet, Jürgen Kuball. RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor. Cell Reports (2016). inserm-01416269

Audrey Benyamine, A. Le Roy, Emilie Mamessier, J. Gertner-Dardenne, C. Castanier, F. Orlanducci, L Pouyet, A. Goubard, Y. Collette, N. Vey, Emmanuel Scotet, R. Castellano, D. Olive. BTN3A molecules considerably improve Vγ9Vδ2T cells-based immunotherapy in acute myeloid leukemia. OncoImmunology (2016). inserm-01416288

Yannick Jacques, Erwan Mortier. Le renouveau de l’interleukine 2 : Modèle revisité et nouvelles applications thérapeutiques. médecine/sciences (2016). inserm-01419855

Mélanie Desbois, Pauline Le Vu, Clélia Coutzac, Elie Marcheteau, Coralie Béal, Magali Terme, Alain Gey, Sébastien Morisseau, Géraldine Teppaz, Lisa Boselli, Yannick Jacques, David Béchard, Eric Tartour, Lydie Cassard, Nathalie Chaput. IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists. Journal of Immunology (2016). inserm-01823361

Leslie Hesnard, François Legoux, Laetitia Gautreau, Melinda Moyon, Olivier Baron, Marie-Claire Devilder, Marc Bonneville, Xavier Saulquin. Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus. European Journal of Immunology (2016). inserm-02547732

Estelle Marion, Ulrich Jarry, Camille Cano, Caroline Savary, Céline Beauvillain, Marie Robbe-Saule, Laurence Preisser, Frédéric Altare, Yves Delneste, Pascale Jeannin, Laurent Marsollier. FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced by Mycobacterium ulcerans and Switch M. ulcerans into a Low Mycolactone Producer. Journal of Immunology (2016). inserm-01284881

Ulrich Jarry, Cynthia Chauvin, Noémie Joalland, Alexandra Léger, Sandrine Minault, Myriam Robard, Marc Bonneville, Lisa Oliver, François M. Vallette, Henri Vié, Claire Pecqueur-Hellman, Emmanuel Scotet. Stereotaxic administrations of allogeneic human Vγ9Vδ2 T cells efficiently control the development of human glioblastoma brain tumors. OncolImmunology (2016). inserm-01342603

Amandine Le Bourgeois, Pierre Peterlin, Thierry Guillaume, Jacques Delaunay, Alix Duquesne, Steven Le Gouill, Philippe Moreau, Mohamad Mohty, Loïc Campion, Patrice Chevallier. Higher Early Monocyte and Total Lymphocyte Counts Are Associated with Better Overall Survival after Standard Total Body Irradiation, Cyclophosphamide, and Fludarabine Reduced-Intensity Conditioning Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Adults. Biology of Blood and Marrow Transplantation (2016). inserm-01419441

EQUIPE 2

A. Brocard, Ac. Knol, C. Bossard, M. Denis, G. Quereux, M. Saint-Jean, L. Peuvrel, Amir Khammari, G. Blancho, Jacques Dantal, Brigitte Dréno. Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients. Acta Dermato-Venereologica (2016). inserm-01406472

R. Gutzmer, Licia Rivoltini, E. Levchenko, A. Testori, J. Utikal, Paolo Antonio Ascierto, L. Demidov, J. Grob, Ruggero Ridolfi, D. Schadendorf, P. Queirolo, Alessandra Santoro, C. Loquai, Brigitte Dréno, A. Hauschild, E. Schultz, T. Lesimple, N. Vanhoutte, B. Salaun, M. Gillet, S. Jarnjak, P. De Sousa Alves, J. Louahed, V. Brichard, F. Lehmann. Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study. European Society for Medical Oncology (2016). inserm-01406639

Jm Castillo, Ac. Knol, J. M. Nguyen, Amir Khammari, M. Saint-Jean, B. Dréno. Immunohistochemical markers of advanced basal cell carcinoma: CD56 is associated with a lack of response to vismodegib. European Journal of Dermatology (2016). inserm-01406694

Mario E. Lacouture, Brigitte Dréno, Paolo Antonio Ascierto, Reinhard Dummer, N. Basset-Seguin, Kate Fife, Scott Ernst, Lisa Licitra, Rogerio I. Neves, Ketty Peris, Susana Puig, Jonas Sokolof, Aleksandar Sekulic, Axel Hauschild, Rainer Kunstfeld. Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma. The Oncologist (2016). inserm-01406794

P. Saiag, R. Gutzmer, P. A. Ascierto, M. Maio, J.-J. Grob, P. Murawa, Brigitte Dréno, M. Ross, J. Weber, A. Hauschild, P. Rutkowski, A. Testori, E. Levchenko, A. Enk, L. Misery, C. Vanden Abeele, I. Vojtek, O. Peeters, V. Brichard, P. Therasse. Prospective assessment of a gene signature potentially predictive of clinical benefit in metastatic melanoma patients following MAGE-A3 immunotherapeutic (PREDICT). Annals of Oncology (2016). inserm-01407384

Paolo Ascierto, Grant Mcarthur, Brigitte Dréno, Victoria Atkinson, Gabrielle Liszkay, Anna Maria Di Giacomo, Mario Mandalà, Lev Demidov, Daniil Stroyakovskiy, Luc Thomas, Luis De La Cruz-Merino, Caroline Dutriaux, Claus Garbe, Yibing Yan, Matthew Wongchenko, Ilsung Chang, Jessie Hsu, Daniel Koralek, Isabelle Rooney, Antoni Ribas, James Larkin. Cobimetinib combined with vemurafenib in advanced BRAF V600 -mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial. Lancet Oncology (2016). inserm-01407426

Cédric Rat, Gaelle Quereux, Charlotte Grimault, Jérémy Fernandez, Mickael Poiraud, Aurélie Gaultier, Anicet Chaslerie, Jacques Pivette, Amir Khammari, Brigitte Dreno, Jean-Michel Nguyen. Inclusion of populations at risk of advanced melanoma in an opportunistic targeted screening project involving general practitioners. Scandinavian Journal of Primary Health Care (2016). inserm-01407477

Kilian Wistuba-Hamprecht, Alexander Martens, Karin Haehnel, Marnix Geukes Foppen, Jianda Yuan, Michael Postow, Phillip Wong, Emanuela Romano, Amir Khammari, Brigitte Dréno, Mariaelena Capone, Paolo Ascierto, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Anis Larbi, Bastian Schilling, Dirk Schadendorf, Jedd Wolchok, Christian Blank, Graham Pawelec, Claus Garbe, Benjamin Weide. Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab. European Journal of Cancer (2016). inserm-01408787

Tung Phan, Brigitte Dreno, Antonio Charlys da Costa, Linlin Li, Patricia Orlandi, Xutao Deng, Beatrix Kapusinszky, Juliana Siqueira, Anne-Chantal Knol, Franck Halary, Jacques Dantal, Kathleen Alexander, Patricia Pesavento, Eric Delwart. A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides). Virology (2016). inserm-01408880

Anne Knol, Audrey Vallée, Guillaume Herbreteau, Jean-Michel Nguyen, Aurélie Gaultier, Emilie Varey, Sandrine Théoleyre, Mélanie Saint-Jean, Lucie Peuvrel, Anabelle Brocard, Gaelle Quereux, Amir Khammari, Marc G. Denis, Brigitte Dréno. Clinical significance of BRAF mutation status in circulating tumor DNA of metastatic melanoma patients at baseline. Experimental Dermatology (2016). inserm-01408920

Alexander Martens, Kilian Wistuba-Hamprecht, Jianda Yuan, Michael Postow, Phillip Wong, Mariaelena Capone, Gabriele Madonna, Amir Khammari, Bastian Schilling, Antje Sucker, Dirk Schadendorf, Peter Martus, Brigitte Dreno, Paolo Ascierto, Jedd Wolchok, Graham Pawelec, Claus Garbe, Benjamin Weide. Increases in Absolute Lymphocytes and Circulating CD4+ and CD8+ T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab. Clinical Cancer Research (2016). inserm-01408937

Cécile Frenard, Anne-Chantal Knol, Marie Lemoigne, Amir Khammari, Brigitte Dreno. Effect of indoleamine 2,3-dioxygenase expressed by foetal fibroblasts on melanoma cells. Experimental Dermatology (2016). inserm-01409073

Alexander Martens, Kilian Wistuba-Hamprecht, Marnix Geukes Foppen, Jianda Yuan, Michael Postow, Phillip Wong, Emanuela Romano, Amir Khammari, Brigitte Dreno, Mariaelena Capone, Paolo Ascierto, Anna Maria Di Giacomo, Michele Maio, Bastian Schilling, Jessica Hassel, Thomas Eigentler, Peter Martus, Jedd Wolchok, Christian Blank, Graham Pawelec, Claus Garbe, Benjamin Weide, Antje Sucker, Dirk Schadendorf. Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab. Clinical Cancer Research (2016). inserm-01409624

Lucie Peuvrel, Gaelle Quéreux, Mélanie Saint-Jean, A. Brocard, Jean Michel Nguyen, Amir Khammari, Anne Chantal Knol, Emilie Varey, Brigitte Dréno. Profile of vemurafenib-induced severe skin toxicities. Journal of the European Academy of Dermatology and Venereology (2016). inserm-01819814

Guillaume Aubin, Stanimir Kambarev, Pascale Bémer, Paul Lawson, Stéphane Corvec. Draft Genome Sequence of Highly Rifampin-Resistant Propionibacterium namnetense NTS 31307302T Isolated from a Patient with a Bone Infection. Genome Announcements (2016). inserm-01822375

Guillaume Aubin, Stanimir Kambarev, Aurélie Guillouzouic, Didier Lepelletier, Pascale Bémer, Stéphane Corvec. Draft Genome Sequences of Four Propionibacterium acnes Strains Isolated from Implant-Related Infections. Genome Announcements (2016). inserm-01408920

Guillaume Aubin, Pascale Bémer, Stanimir Kambarev, Nisha Patel, Olivier Lemenand, J Caillon, PA Lawson, Stéphane Corvec. Propionibacterium namnetense sp. nov., isolated from a human bone infection. International Journal of Systematic and Evolutionary Microbiology (2016). inserm-01408920

Ferdaous Allagui, Carole Achard, Clarisse Panterne, Chantal Combredet, Nathalie Labarrière, Brigitte Dréno, Amel Benammar Elgaaied, Daniel Pouliquen, Frédéric Tangy, Jean-François Fonteneau, Marc Grégoire, Nicolas Boisgerault. Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus. Current Gene Therapy (2016). inserm-01480242

Tiphaine Parrot, Romain Oger, Houssem Benlalam, Diane Raingeard de La Blétière, Nicolas Jouand, Anne Coutolleau, Laurence Preisser, Amir Khammari, Brigitte Dréno, Philippe Guardiola, Yves Delneste, Nathalie Labarrière, Nadine Gervois. CD40L confers helper functions to human intra-melanoma class-I-restricted CD4 + CD8 + double positive T cells. OncoImmunology (2016). inserm-01702809

Simon, S., Vignard, V., Florenceau, L., Khammari, A., Dreno, B., Lang, F., Labarriere, N. Manipulating PD-1 axis to generate melanoma-specific high avidity CD8 T cells for adoptive cell transfer for. European Journal of Immunology (2016).

Simon, S., Vignard, V., Florenceau, L., Khammari, A., Lang, F., Labarriere, N. PD-1 blockade induces quantitative and qualitative changes within a vast and common antigenspecific T cell repertoire in melanoma treated patients. European Journal of Immunology (2016).

Tiphaine Parrot, Mathilde Allard, Romain Oger, Houssem Benlalam, Diane Raingeard de La Blétìère, Anne Coutolleau, Laurence Preisser, Juliette Desfrançois, Amir Khammari, Brigitte Dréno, Nathalie Labarrière, Yves Delneste, Philippe Guardiola, Nadine Gervois. IL-9 promotes the survival and function of human melanoma-infiltrating CD4 + CD8 + double-positive T cells. European Journal of Immunology (2016). inserm-01319366

EQUIPE 3

Maud Charpentier, Mikael Croyal, Delphine Carbonnelle, Agnès Fortun, Laetitia Florenceau, Catherine Rabu, Michel Krempf, Nathalie Labarrière, François Lang. IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens. Oncotarget (2016). inserm-01409602

EQUIPE 4

Jean-Francois Fonteneau. Oncolytic Viruses and Immune Checkpoint Inhibitors. Immunotherapy (2016)

Jean-Francois Fonteneau, Fabienne Brilot, Christian Münz, Monique Gannagé. The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer. Journal of Immunology (2016). inserm-01285160

Fatima El Bahhaj, Iza Denis, Pichavant Loic, Régis Delatouche, Floraine Collette, Camille Linot, Daniel Pouliquen, Marc Grégoire, Valérie Héroguez, Christophe Blanquart, Philippe Bertrand. Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy. Theranostics (2016). inserm-01299450

Vincent Zwick, Alessandra Nurisso, Claudia Simões-Pires, Samuel Bouchet, Nadine Martinet, Attila Lehotzky, Judit Ovadi, Muriel Cuendet, Christophe Blanquart, Philippe Bertrand. Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates. Bioorganic and Medicinal Chemistry Letters (2016). inserm-01299475

David Roulois, Sophie Deshayes, Marie-Noëlle Guilly, Joëlle Nader, Charly Liddell, Myriam Robard, Philippe Hulin, Amal Ouacher, Vanessa Le Martelot, Jean-François Fonteneau, Marc Grégoire, Christophe Blanquart, Daniel Pouliquen. Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine. Oncotarget (2016). inserm-01306838

Florent Malard, Myriam Labopin, Patrice Chevallier, Thierry Guillaume, Alix Duquesne, Fanny Rialland, Sophie Derenne, Pierre Peterlin, Anne-Gaelle Leauté, Eolia Brissot, Marc Gregoire, Philippe Moreau, Philippe Saas, Béatrice Gaugler, Mohamad Mohty. Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival. Blood (2016). inserm-01408681

Carole Achard, Jean-Baptiste Guillerme, Daniela Bruni, Nicolas Boisgerault, Chantal Combredet, Frédéric Tangy, Nolwenn Jouvenet, Marc Grégoire, Jean-François Fonteneau. Oncolytic measles virus induces Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells. Oncoimmunology (2016). inserm-01480165

Senan M. d’Almeida, Gilles Kauffenstein, Charlotte Roy, Laetitia Basset, Loukas Papargyris, Daniel Henrion, Véronique Catros, Norbert Ifrah, Philippe Descamps, Anne Croue, Pascale Jeannin, Marc Grégoire, Yves Delneste, Julie Tabiasco. The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27. OncoImmunology (2016). inserm-01385209

Anne-Laure Chéné, Sènan d’Almeida, Thibaut Blondy, Julie Tabiasco, Sophie Deshayes, Jean-François Fonteneau, Laurent Cellerin, Yves Delneste, Marc Grégoire, Christophe Blanquart. Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages. Journal of Thoracic Oncology (2016). inserm-01386814

EQUIPE 5

Dan Li, Adrien Breiman, Jacques Le Pendu, Mieke Uyttendaele. Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses. Frontiers in microbiology (2016). inserm-01406298

Miranda De Graaf, Relja Beck, Simone Caccio, Birgitta Duim, Pieter Fraaij, Françoise Le Guyader, Marc Lecuit, Jacques Le Pendu, Emmie De Wit, Constance Schultsz. Sustained fecal-oral human-to-human transmission following a zoonotic event. Current Opinion in Virology (2016). inserm-01445250

Le Pendu J. Rydell GE, Nasir W, Larson G. Human norovirus receptors. Viral Gastroenteritis ; molecular epidemiology and pathogenesis. Academic Press, Elsevier (2016)

Adrien Breiman, Maria Dolores Lopez Robles, Sophie De Carné Trécesson, Klara Echasserrieau, Karine Bernardeau, Kurt Drickamer, Anne Imberty, Sophie Barillé-Nion, Frédéric Altare, Jacques Le Pendu. Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin). Oncotarget (2016). inserm-01280841

EQUIPE 6

Angélique Montagu, Marie-Laure Joly-Guillou, Elisabeth Rossines, Jérôme Cayon, Marie Kempf, Patrick Saulnier. Stress Conditions Induced by Carvacrol and Cinnamaldehyde on Acinetobacter baumanii. Frontiers in microbiology (2016). hal-01362226

Angélique Montagu, Marie-Laure Joly-Guillou, Catherine Guillet, Jérôme Bejaud, Elisabeth Rossines, Patrick Saulnier. Demonstration of the interactions between aromatic compound-loaded lipid nanocapsules and Acinetobacter baumanii bacterial membrane. International Journal of Pharmaceutics (2016). hal-01392250

Anita Umerska, Viviane Cassisa, Nada Matougui, Marie-Laure Joly-Guillou, Matthieu Eveillard, Patrick Saulnier. Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants. European Journal of Pharmaceutics and Biopharmaceutics (2016). hal-01413267

Daniel Sanhueza, Christine Chevillon, Rita Colwell, Jérémie Babonneau, Estelle Marion, Laurent Marsollier, Jean-Francois Guégan. Chitin promotes Mycobacterium ulcerans growth. FEMS Microbiology Ecology (2016). inserm-01313879

Solange Meyin A Ebong, Elsa Petit, Philippe Le Gall, Ping-Ping Chen, Nico Nieser, Eric Guilbert, Flobert Njiokou, Laurent Marsollier, Jean-François Guégan, Dominique Pluot-Sigwalt, Sara Eyangoh, Myriam Harry. Molecular Species Delimitation and Morphology of Aquatic and Sub-Aquatic Bugs (Heteroptera) in Cameroon. PLoS ONE (2016). inserm-01333894

Aaron Morris, Jean-François Guégan, Demetra Andreou, Laurent Marsollier, Kevin Carolan, Marie Le Croller, Daniel Sanhueza, Rodolphe Gozlan. Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans. Science Advances (2016). inserm-01421033

A. Al Atrouni, Marie Kempf, M. Eveillard, R. Rafei, M. Hamze, M.-L. Joly-Guillou. First report of Oxa-72-producing Acinetobacter calcoaceticus in Lebanon. New Microbes and New Infections (2016). inserm-01815693

Ahmad Al atrouni, Monzer Hamze, Tamima Jisr, Carole Lemarié, Matthieu Eveillard, Marie-Laure Joly-Guillou, Marie Kempf. Wide spread of OXA-23-producing carbapenem-resistant Acinetobacter baumannii belonging to clonal complex II in different hospitals in Lebanon. International Journal of Infectious Diseases (2016). inserm-01822360

Hélène Pailhoriès, Marie Kempf, Olivier Belmonte, Marie-Laure Joly-Guillou, Matthieu Eveillard. First case of OXA-24-producing Acinetobacter baumannii in cattle from Reunion Island, France. International Journal of Antimicrobial Agents (2016). inserm-01822364

Anais Hérivaux, Hélène Pailhoriès, Catherine Quinqueneau, Carole Lemarié, Marie Joly-Guillou, N Ruvoen, M Eveillard, M Kempf. First report of carbapenemase-producing Acinetobacter baumannii carriage in pets from the community in France. International Journal of Antimicrobial Agents (2016). inserm-01822397

Ahmad Al atrouni, Marie-Laure Joly-Guillou, Monzer Hamze, Marie Kempf. Emergence of NDM-1 and OXA-72 producing Acinetobacter pittii clinical isolates in Lebanon. New Microbes and New Infections (2016). inserm-01822432

Ok-Ryul Song, Estelle Marion, Yannick Comoglio, Jérémie Babonneau, Nathalie Guérineau, Guillaume Sandoz, Edouard Yeramian, Priscille Brodin, Laurent Marsollier. La mycolactone : Les surprenantes propriétés analgésiques d’une toxine mycobactérienne. médecine/sciences (2016). inserm-01822467

Ahmad Al Atrouni, Marie-Laure Joly-Guillou, Monzer Hamze, Marie Kempf. Reservoirs of Non-baumannii Acinetobacter Species. Frontiers in Microbiology (2016). inserm-01822491

Estelle Marion, Annick Chauty, Marie Kempf, Yannick Le Corre, Yves Delneste, Anne Croue, Laurent Marsollier. Clinical Features of Spontaneous Partial Healing During Mycobacterium ulcerans Infection. Open Forum Infectious Diseases (2016). inserm-01281366

EQUIPE 7

Caroline Poli, Mathieu Laurichesse, Octavie Rostan, Delphine Rossille, Pascale Jeannin, Martine Drouet, Gilles Renier, Alain Chevailler, Karin Tarte, Claude Bendavid, Céline Beauvillain, Patricia Amé-Thomas. Comparison of two enzymatic immunoassays, high resolution mass spectrometry method and radioimmunoassay for the quantification of human plasma histamine. Journal of Pharmaceutical and Biomedical Analysis (2016). hal-01231429

Ohayon D, De Chiara A, Chapuis N, Candalh C, Mocek J, Ribeil JA, Haddaoui L, Ifrah N, Hermine O, Bouillaud F, Frachet P, Bouscary D, Witko-Sarsat V. Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia. Scientific Reports (2016). hal-01398304

Yuichi Morozumi, Fayçal Boussouar, Minjia Tan, Apirat Chaikuad, Mahya Jamshidikia, Gozde Colak, Huang He, Litong Nie, Carlo Petosa, Maud De Dieuleveult, Sandrine Curtet, Anne-Laure Vitte, Clothilde Rabatel, Alexandra Debernardi, François-Loïc Cosset, Els Verhoeyen, Anouk Emadali, Norbert Schweifer, Davide Gianni, Marta Gut, Philippe Guardiola, Sophie Rousseaux, Matthieu Gérard, Stefan Knapp, Yingming Zhao, Saadi Khochbin. Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. Journal of molecular cell biology (2016). hal-01415782

Amélie Trinquand, Nuno R. Santos, Christine Tran Quang, Francesca Rocchetti, Benedetta Zaniboni, Mohamed Belhocine, Cindy da Costa, Jesus Ludovic Lhermitte, Melania Tesio, Michael Dussiot, François-Loïc Cosset, Els Verhoeyen, Francoise Pflumio, Norbert Ifrah, Hervé Dombret, Salvatore Spicuglia, Lucienne Chatenoud, David-Alexandre Gross, Olivier Hermine, Elizabeth Macintyre, Jacques Ghysdael, Vahid Asnafi. Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppresive Pathway in T-cell Leukemia. Cancer Discovery (2016). hal-01460133

A. Desjonqueres, P. Chevallier, X. Thomas, F. Huguet, T. Leguay, M. Bernard, J.O. Bay, E. Tavernier, A. Charbonnier, F. Isnard, M. Hunault, P. Turlure, M. Renaud, J.N. Bastie, C. Himberlin, S. Lepretre, B. Lioure, V. Lheritier, V. Asnafi, K. Beldjord, M. Lafage-Pochitaloff, M.C. Bene, N. Ifrah, H. Dombret. Acute lymphoblastic leukemia relapsing after first-line pediatric-inspired therapy: a retrospective GRAALL study. Blood Cancer Journal (2016). hal-01792626

Philippe Rousselot, Marie Magdelaine Coudé, Nicola Gokbuget, Carlo Gambacorti Passerini, Sandrine Hayette, Jean-Michel Cayuela, Françoise Huguet, Thibaut Leguay, Patrice Chevallier, Celia Salanoubat, Caroline Bonmati, Magda Alexis, Mathilde Hunault, Sylvie Glaisner, Philippe Agape, Christian Berthou, Eric Jourdan, José Fernandes, Laurent Sutton, Anne Banos, Oumedaly Reman, Bruno Lioure, Xavier Thomas, Norbert Ifrah, Marina Lafage-Pochitaloff, Anne Bornand, Laure Morisset, Valérie Robin, Heike Pfeifer, Andre Delannoy, Josep Ribera, Renato Bassan, Marc Delord, Dieter Hoelzer, Herve Dombret, Oliver G. Ottmann. Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL. Blood (2016). hal-01800020

A. Simon, JF. Subra, P. Guilpain, P. Jeannin, P. Pignon, S. Blanchard, E. Garo, S. Jaillon, A. Chevailler, G. Renier, X. Puéchal, B. Bottazzi, A. Mantovani, Y. Delneste, JF. Augusto. Detection of Anti-Pentraxin-3 Autoantibodies in ANCA-Associated Vasculitis. PLoS ONE (2016). inserm-01273293

P Cunin, Céline Beauvillain, Charline Miot, Jean-François Augusto, Laurence Preisser, Simon Blanchard, Pascale Pignon, M Scotet, Erwan Garo, Isabelle Fremaux, Alain Chevailler, Jean-François Subra, Patrick Blanco, Mark Wilson, Pascale Jeannin, Yves Delneste. Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses. Cell Death and Disease (2016). inserm-01312769

Corentin Orvain, Damien Luque Paz, Irène Dobo, Laurane Cottin, Geneviève Le Calvez, Aurélie Chauveau, Mélanie Mercier, J. Farhi, Françoise Boyer, Jean-Christophe Ianotto, Briac Guibourg, Marie-Christine Rousselet, Marc Zandecki, Norbert Ifrah, Mathilde Hunault-Berger, Valérie Ugo, Franck Genevieve. Circulating Cd34+ cell count differentiates primary myelofibrosis from other Philadelphia-negative myeloproliferative neoplasms:a pragmatic study. Annals of Hematology (2016). inserm-01382431

Antoine Caillon, Céline Grenier, Linda Grimaud, Emilie Vessieres, Anne-Laure Guihot, Simon Blanchard, Eric Lelievre, Marie Chabbert, Etienne Foucher, Pascale Jeannin, Céline Beauvillain, Pierre Abraham, Laurent Loufrani, Yves Delneste, Daniel Henrion. The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T cells-dependent interleukin-17 production. Cardiovascular Research (2016). inserm-01382460

Stéphane Leprêtre, Aurore Touzart, Thomas Vermeulin, Jean-Michel Picquenot, Aline Schmidt-Tanguy, Gilles Salles, Thierry Lamy, Marie-Christine Béné, Emmanuel Raffoux, Françoise Huguet, Patrice Chevallier, Serge Bologna, Réda Bouabdallah, Jacques Bénichou, Josette Brière, Anne Moreau, Valérie Tallon-Simon, Stéphanie Seris, Carlos Graux, Vahid Asnafi, Norbert Ifrah, Elizabeth Macintyre, Hervé Dombret. Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study. Journal of Clinical Oncology (2016). inserm-01411210

C. Willekens, O. Blanchet, A. Renneville, P. Cornillet-Lefebvre, C. Pautas, R Guieze, N Ifrah, H Dombret, E Jourdan, C Preudhomme, N Boissel, French AML Intergroup. Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX1-RUNX1T1-positive acute myeloid leukemia: results of the French CBF-2006 trial. Haematologica (2016). inserm-01817446

Nicolas Duployez, Jean-Baptiste Micol, Nicolas Boissel, Arnaud Petit, Sandrine Geffroy, Maxime Bucci, Hélène Lapillonne, Aline Renneville, Guy Leverger, Norbert Ifrah, Hervé Dombret, Omar Abdel-Wahab, Eric Jourdan, Claude Preudhomme. Unlike ASXL1 and ASXL2 mutations, ASXL3 mutations are rare events in acute myeloid leukemia with t(8;21). Leukemia & lymphoma (2016). inserm-01820362

EQUIPE 8

Guillemette Bernadou, Mario Campone, Jean-Louis Merlin, Valérie Gouilleux-Gruart, Thomas Bachelot, François Lokiec, Keyvan Rezai, Monica Arnedos, Véronique Diéras, Martha Jimenez, Gilles Paintaud, David Ternant. Influence of tumour burden on trastuzumab pharmacokinetics in HER2 positive non-metastic breast cancer. British Journal of Clinical Pharmacology (2016). hal-01252102

Maëva Lion, Alexandre Harlé, Julia Salleron, Carole Ramacci, Mario Campone, Jean-Louis Merlin. Trastuzumab as a preoperative monotherapy does not inhibit HER2 downstream signaling in HER2-positive breast cancer. Oncology Letters (2016). hal-01418865

E. Véquaud, G. Desplanques, P. Jézéquel, P. Juin, S. Barillé-Nion. Survivin contributes to DNA repair by homologous recombination in breast cancer cells. Breast Cancer Research and Treatment (2016). inserm-01273318

Mbaye Diaw Dioum, Matar Seck, Virginie Silvestre, Aurélien Planchat, Denis Loquet, Steven Lohard, Sophie Barille-Nion, Gerald Remaud, Richard Robins, Illa Tea. A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines. Planta Medica (2016). inserm-01333918

Sonia Das, Mathilde Romagnoli, Nora Mineva, Sophie Barillé-Nion, Pascal Jézéquel, Mario Campone, Gail Sonenshein. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Breast Cancer Research (2016). inserm-01333949

J Le Pen, Laurent Maillet, Kristopher Sarosiek, Céline Vuillier, Fabien Gautier, Sylvie Montessuit, Jean-Claude Martinou, Anthony Letaï, Frédérique Braun, Philippe Juin. Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Cell Death and Disease (2016). inserm-01333971

David Montoir, Sophie Barillé-Nion, Alain Tonnerre, Philippe Juin, Muriel Duflos, Marc-Antoine Bazin. Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90. European Journal of Medicinal Chemistry (2016). inserm-01334013

Duc Duy Vo, Isabelle Rouaud, Francoise Le Devehat, Fabien Gautier, Sophie Barillé-Nion, Philippe Juin, Nicolas Levoin, Joël Boustie, René Grée. Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic Systems Against B16-F10 Melanoma Cancer Cells. Medicinal Chemistry (2016). inserm-01406309

Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie De Carné Trécesson, Aurélie Fétiveau, Kristopher Sarosie, Florian Bock, Frédérique Braun, Anthony Letai, Stephen Tait, Fabien Gautier, Philippe Juin. Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance. Cell Reports (2016). inserm-01416194

Carole Gourmelon, Heloise Bourien, Paule Augereau, Anne Patsouris, JJean-Sébastien Frenel, Mario Campone. Vinflunine for the treatment of breast cancer. Expert Opinion on Pharmacotherapy (2016). inserm-01822667

Suzette Delaloge, Thomas Bachelot, François-Clément Bidard, Marc Espie, Etienne Brain, Hervé Bonnefoi, Joseph Gligorov, Florence Dalenc, Anne-Claire Hardy-Bessard, David Azria, Jean-Philippe Jacquin, Jérôme Lemonnier, William Jacot, Anthony Gonçalvès, Gérard Ganem, Charles Coutant, Thierry Petit, Frédérique Penault-Lorca, Marc Debled, Mario Campone, Christelle Levy, Bruno Coudert, Alain Lortholary, Laurence Venat-Bouvet, Julien Grenier, Hugues Bourgeois, Bernard Asselain, Johanna Arvis, Martine Castro, Anne Tardivon, David Cox, Patrick Arveux, Corinne Balleyguier, Fabrice André, Roman Rouzier. Dépistage du cancer du sein : en route vers le futur. Bulletin du Cancer (2016). inserm-01822723

Diane-Charlotte Imbs, Véronique Diéras, Thomas Bachelot, Mario Campone, Nicolas Isambert, Florence Joly, Marta Jimenez, Thierry Lafont, Etienne Chatelut. Pharmacokinetic interaction between pazopanib and cisplatin regimen. Cancer Chemotherapy and Pharmacology (2016). inserm-01822936

EQUIPE 9

Mazene Hochane, Valérie Trichet, Claire Pecqueur, Pierre Avril, Lisa Oliver, Jérôme Denis, Régis Brion, Jérôme Amiaud, Alain Pineau, Philippe Naveilhan, Dominique Heymann, François M. Vallette, Christophe Olivier. Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic Phenotype In Premalignant MSC. Stem Cells (2016). inserm-01398601

Lisa Oliver, Christophe Olivier, Francois M Vallette. Prostaglandin E2 plays a major role in glioma resistance and progression. Translational Cancer Research (2016). inserm-01398631

Elise Petit, François Cartron, Lisa Oliver, François Vallette. The phosphorylation of Metaxin 1 controls Bak activation during TNFα induced cell death. Cellular Signalling (2016). inserm-01398677

Carmen Brenner, Judith Luciani, Martin Bizet, Matladi Ndlovu, Eleonore Josseaux, Sarah Dedeurwaerder, Emilie Calonne, Pascale Putmans, Pierre-François Cartron, Matthieu Defrance, François Fuks, Rachel Deplus. The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent. Oncotarget (2016). inserm-01414047

L. Dollet, J. Magré, M. Joubert, C Le May, A. Ayer, L. Arnaud, C. Pecqueur, V. Blouin, B. Cariou, X. Prieur. Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode. Scientific Reports (2016). inserm-01414140

Mathilde Cheray, Romain Pacaud, Arulraj Nadaradjane, Lisa Oliver, François Vallette, Pierre-François Cartron. Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth. Theranostics (2016). inserm-01414173

Vassilios Myrianthopoulos, Pierre-Francois Cartron, Zita Liutkeviciute, Saulius Klimasauskas, Daumantas Matulis, Christian Bronner, Nadine Martinet, Emmanuel Mikros. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. European Journal of Medicinal Chemistry (2016). inserm-01414204

Elias A. El-Habr, Gustavo Luiz Dubois, Fanny Burel-Vandenbos, Alexandra Bogeas, Joanna Lipecka, Laurent Turchi, François-Xavier Lejeune, Paulo Lucas Cerqueira Coelho, Kunihiko Yamaki, Bryan M. Wittmann, Mohamed Fareh, Emna Mahfoudhi, Maxime Janin, Ashwin Narayanan, Ghislaine Morvan-Dubois, Charlotte Schmitt, Maïté Verreault, Lisa Oliver, Ariane Sharif, Johan Pallud, Bertrand Devaux, Stéphanie Puget, Penelope Korkolopoulou, Pascale Varlet, Chris Ottolenghi, Isabelle Plo, Vivaldo Moura-Neto, Thierry Virolle, Hervé Chneiweiss, Marie-Pierre Junier. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta Neuropathologica (2016). inserm-01481051

Julien Fleurence, Denis Cochonneau, Sophie Fougeray, Lisa Oliver, Fanny Geraldo, Mickaël Terme, Mylène Dorvillius, Delphine Loussouarn, François Vallette, Francois Paris, Stéphane Birklé. Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside. Oncotarget (2016). inserm-01319327

Sophie Fougeray, Julien Fleurence, Sébastien Faraj, Meriem Bahri, Denis Cochonneau, Mickaël Terme, Marc-David Leclair, Estelle Thébaud, François Paris, Stéphane Birklé. O-acetylated gangliosides: Structure, biosynthesis, immunogenicity, functions and their potential for cancer immunotherapy. Journal of Cancer Research and Therapeutics (2016). inserm-01419857

Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, [et al], Julie Gavard, [et al], François Vallette, [et al], Wei-Xing Zong, Antonio Zorzano, Susu M Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016). hal-01396896

EQUIPE 10

Paola Storti, Denise Toscani, Irma Airoldi, Valentina Marchica, Sophie Maïga, Marina Bolzoni, Elena Fiorini, Nicolletta Campanini, Eugenia Martella, Cristina Mancini, Daniela Guasco, Valentina Ferri, Gaetano Donofrio, Franco Aversa, Martine Amiot, Nicola Giuliani. The anti-tumoral effect of lenalidomide is increased in vivo by hypoxia-inducible factor (HIF)-1α inhibition in myeloma cells. Haematologica (2016). inserm-01285193

Punnoose EA, Leverson JD, Peale F, Boghaert ER, Belmont LD, Tan N, Young A, Mitten M, Ingalla E, Darbonne WC, Oleksijew A, Tapang P, Yue P, Oeh J, Lee L, Maiga S, Fairbrother WJ, Amiot M, Souers AJ, Sampath D. Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models. Mol Cancer Ther (2016). inserm-01311318

Mohamed Amine Hamouda, Arnaud Jacquel, Guillaume Robert, Alexandre Puissant, Valentine Richez, Roméo Cassel, Nina Fenouille, Sandrine Roulland, Jérôme Gilleron, Emmanuel Griessinger, Alix Dubois, Beatrice Bailly-Maitre, Diego Goncalves, Aude Mallavialle, Pascal Colosetti, Sandrine Marchetti, Martine Amiot, Patricia Gomez-Bougie, Nathalie Rochet, Marcel Deckert, Hervé Avet-Loiseau, Paul Hofman, Jean-Michel Karsenti, P. Y. Jeandel, Claudine Blin-Wakkach, Bertrand Nadel, Thomas Cluzeau, Kenneth C. Anderson, Jean-Gabriel Fuzibet, Patrick Auberger, Frederic Luciano. BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice. The Journal of Experimental Medecine (2016). inserm-01353362

Matthieu Hanf, David Chiron, Sophie De Visme, Cyrille Touzeau, Hervé Maisonneuve, Henry Jardel, Catherine Pellat-Deceunynck, Martine Amiot, Steven Le Gouill. The REFRACT-LYMA cohort study: a French observational prospective cohort study of patients with mantle cell lymphoma. BMC Cancer (2016). inserm-01381110

Cyrille Touzeau, Philippe Moreau. How I treat extramedullary myeloma. Blood (2016)

Patricia Gomez-Bougie, Christelle Dousset, Géraldine Descamps, A. Schnitzler, Logan Audiger, Arnaud Tessier, Didier Dubreuil, Jacques Lebreton, Catherine Pellat-Deceunynck, Martine Amiot. The selectivity of Marinopyrrole A to induce apoptosis in MCL1 high BCL2 low expressing myeloma cells is related to its ability to impair protein translation. British Journal of Haematology (2016). inserm-01419215

Marco Ladetto, C. Buske, M. Hutchings, M. Dreyling, G Gaidano, S. Le Gouill, S. Luminari, C. Pott, A. Zamo, E. Zucca. ESMO consensus conference on malignant lymphoma: general perspectives and recommendations for prognostic tools in mature B-cell lymphomas and chronic lymphocytic leukaemia. Annals of Oncology (2016). inserm-01419340

Vincent Ribrag, Serge Koscielny, Jacques Bosq, Thibaut Leguay, Olivier Casasnovas, Luc-Mathieu Fornecker, Christian Recher, Hervé Ghesquieres, Franck Morschhauser, Stéphane Girault, Steven Le Gouill, Mario Ojeda-Uribe, Clara Mariette, Jerome Cornillon, Guillaume Cartron, Veronique Verge, Catherine Chassagne-Clément, Hervé Dombret, Bertrand Coiffier, Thierry Lamy, Hervé Tilly, Gilles Salles. Rituximab and dose-dense chemotherapy for adults with Burkitt’s lymphoma: a randomised, controlled, open-label, phase 3 trial. The Lancet (2016). inserm-01419476

Mathilde Lamarque, Céline Bossard, Adrien Contejean, Pauline Brice, Marie Parrens, Steven Le Gouill, Josette Brière, Reda Bouabdallah, Danielle Canioni, Herve Tilly, Brigitte Bouchindhomme, Emmanuel Bachy, Richard Delarue, Corinne Haioun, Philippe Gaulard. Brentuximab vedotin in refractory or relapsed peripheral T-cell lymphomas: the French named patient program experience in 56 patients. Haematologica (2016). inserm-01419525

Benoit Tessoulin, P. Ceballos, P. Chevallier, Didier Blaise, Olivier Tournilhac, J. Gauthier, N. Maillard, Reza Tabrizi, S. Choquet, S. Carras, Norbert Ifrah, G. Guillerm, Mohamad Mohty, Herve Tilly, Gérard Socié, J. Cornillon, Olivier Hermine, E. Daguindau, E. Bachy, S. Girault, T. Marchand, L. Oberic, O. Reman, C. Leux, Steven Le Gouill. Allogeneic stem cell transplantation for patients with mantle cell lymphoma who failed autologous stem cell transplantation: a national survey of the SFGM-TC. Bone Marrow Transplantation (2016). inserm-01419584

Christelle Dousset, Sophie Maïga, Patricia Gomez-Bougie, Joy Le Coq, Cyrille Touzeau, Philippe Moreau, Steven Le Gouill, David Chiron, Catherine Pellat-Deceunynck, Agnès Moreau-Aubry, Martine Amiot. BH3 profiling as a tool to identify acquired resistance to venetoclax in multiple myeloma. British Journal of Haematology (2016). inserm-01353369

Patricia Gomez-Bougie, Maxime Halliez, Philippe Moreau, Catherine Pellat-Deceunynck, Martine Amiot. Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis. Cancer Letters (2016). inserm-01385221

David Chiron, Céline Bellanger, Antonin Papin, Benoit Tessoulin, Christelle Dousset, Sophie Maiga, Anne Moreau, Julie Esbelin, Valérie Trichet, Selina Chen-Kiang, Philippe Moreau, Cyrille Touzeau, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunynck. Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma. Blood (2016). inserm-01405674

Cyrille Touzeau, Jeremy Ryan, Jennifer Guerriero, Philippe Moreau, Triona Chonghaile, Steven Le Gouill, Paul Richardson, Kenneth Anderson, Martine Amiot, Anthony Letai. BH3-profiling identifies heterogeneous dependency on Bcl-2 family members in Multiple Myeloma and predicts sensitivity to BH3 mimetics. Leukemia (2016). inserm-01411102

Cyrille Touzeau, P. Moreau. Pomalidomide in the management of relapsed multiple myeloma. Future Oncology (2016). inserm-01411106

Aline Clavert, Zinaida Peric, Eolia Brissot, Florent Malard, Thierry Guillaume, Jacques Delaunay, Viviane Dubruille, Steven Le Gouill, Beatrice Mahe, Thomas Gastinne, Nicolas Blin, Jean-Luc Harousseau, Philippe Moreau, Noel Milpied, Mohamad Mohty, Patrice Chevallier. Late Complications and Quality of Life after Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation (2016). inserm-01419231

EQUIPE 11

Bruno Royer, Minvielle Stéphane, Momar Diouf, Murielle Roussel, Lionel Karlin, Cyrille Hulin, Bertrand Arnulf, Margaret Macro, Cailleres Sylvie, Annie Brion, Sabine Bréchignac, Beladj Karim, Marie Lorraine Chrétien, Marc Wetterwald, Carine Chaleteix, Mourad Tiab, Xavier Leleu, Laurent Frenzel, Laurent Garderet, Sylvain Choquet, Jean-Gabriel Fuzibet, Charles Dauriac, Luc-Matthieu Forneker, Lotfi Benboubker, Thierry Facon, Philippe Moreau, Hervé Avet-Loiseau, Jean-Pierre Marolleau. Bortezomib-doxorubicin-cyclophosphamide-dexamethasone induction followed by stem cell transplantation for primary plasma cell leukemia: a prospective phase II study of the IFM. Journal of Clinical Oncology (2016). inserm-01273359

Florence Magrangeas, Rowan Kuiper, Hervé Avet-Loiseau, Wilfried Gouraud, Catherine Guérin-Charbonnel, Ludovic Ferrer, Alexandre Aussem, Haytham Elghazel, Jérôme Suhard, Henri Der Sakissian, Michel Attal, Nikhil C.Munshi, Pieter Sonneveld, Charles Dumontet, Philippe Moreau, Mark van Duin, Loïc Campion, Stéphane Minvielle. A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Multiple Myeloma Patients. Clinical Cancer Research (2016). inserm-01313506

Niccolò Bolli, Yan-Fu Li, S Sathiaseelan, Keiran Raine, Wendy Jones, Peter Ganly, Federica Cocito, G Bignell, Mike Chapman, A Sperling, K Anderson, Hervé Avet-Loiseau, S Minvielle, Peter Campbell, Nikhil Munshi. A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma. Blood Cancer Journal (2016). inserm-01382540

Cyrille Touzeau, P. Moreau. Pomalidomide in the management of relapsed multiple myeloma. Future Oncology (2016). inserm-01411106

EQUIPE 12

Olivier Coqueret. Senescence : Adaptation to DNA repair targeting drugs ? Cell Cycle (2016). inserm-01405696

Barbara Jonchère, Alexandra Vétillard, Bertrand Toutain, Catherine Guette, Olivier Coqueret. Echappement tumoral lors de la chimiothérapie : un choix entre sénescence et apoptose dans des tumeurs hétérogènes. Bulletin du Cancer (2016). inserm-01405703

EQUIPE 13

C. Ansquer, F. Kraeber-Bodéré. Techniques de médecine nucléaire pour l’imagerie et le traitement des tumeurs neuroendocrines gastro-entéro-pancréatiques. EMC : Radiologie et imagerie médicale, abdominale, digestive (2016).

Jean-François Chatal, Françoise Kraeber-Bodéré, Caroline Bodet-Milin, Caroline Rousseau. Therapeutic Immunoconjugates. Which Cytotoxic Payload: Chemotherapeutic Drug (ADC) or Radionuclide (ARC) ? Current Cancer Therapy Reviews (2016).

Zakaria Halime, M. Frindel, N. Camus, Pierre yves Orain, M. Lacombe, K. Bernardeau, M. Chérel, J.-F. Gestin, A. Faivre-Chauvet, Raphaël Tripier. Correction: New synthesis of phenyl-isothiocyanate C-functionalised cyclams. Bioconjugation and 64Cu phenotypic PET imaging studies of multiple myeloma with the te2a derivative. Organic and Biomolecular Chemistry (2016). hal-01770457

Rabha Kerdjoudj, Miroslav Pniok, Cyrille Alliot, Vojtěch Kubíček, Jana Havlíčková, Frank Rösch, Petr Hermann, Sandrine Huclier-Markai. Scandium(III) complexes of monophosphorus acid DOTA analogues: a thermodynamic and radiolabelling study with 44 Sc from cyclotron and from a 44 Ti/ 44 Sc generator †. Dalton Transactions (2016). inserm-01280135

Holisoa Rajerison, Djibril Faye, Aurélia Roumesy, Nicolas Louaisil, Fabien Boeda, Alain Faivre-Chauvet, Jean-François Gestin, Stéphanie Legoupy. Ionic liquid supported organotin reagents to prepare molecular imaging and therapy agents †. Organic and Biomolecular Chemistry (2016). inserm-01280171

Caroline Bodet-Milin, Françoise Kraeber-Bodéré, Thomas Eugène, François Guérard, Joëlle Gaschet, Clément Bailly, Marie Mougin, Mickaël Bourgeois, Alain Faivre-Chauvet, Michel Chérel, Patrice Chevallier. Radioimmunotherapy for Treatment of Acute Leukemia. Seminars in Nuclear Medicine (2016). inserm-01280232

Ghislaine Béhar, Axelle Renodon-Cornière, Barbara Mouratou, Frédéric Pecorari. Affitins as robust tailored reagents for affinity chromatography purification of antibodies and non-immunoglobulin proteins. Journal of Chromatography A (2016). inserm-01292506

Claudia Fernandes, Raquel Dos Santos, Stella Ottengy, Aline Canani Viecinski, Ghislaine Béhar, Barbara Mouratou, Frédéric Pecorari, Cecilia Roque. Affitins for protein purification by affinity magnetic fishing. Journal of Chromatography A (2016). inserm-01342446

François Guérard, Yong-Sok Lee, Kwamena Baidoo, Jean-François Gestin, Martin W. Brechbiel. Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts. Chemistry Journal (2016). inserm-01387016

Valentina Kalichuk, Ghislaine Béhar, Axelle Renodon-Cornière, Georgi Danovski, Gonzalo Obal, Jacques Barbet, Barbara Mouratou, Frédéric Pécorari. The archaeal « 7kDa DNA-binding » proteins: extended characterization of an old gifted family. Scientific Reports (2016). inserm-01398571

Dorothée Goulon, Hatem Necib, Brice Henaff, Caroline Rousseau, Thomas Carlier, Françoise Kraeber-Bodere. Quantitative evaluation of Therapeutic response by FDG-PET–CT in Metastatic Breast Cancer. Frontiers in Medicine (2016). inserm-01414260

Clément Bailly, Caroline Bodet-Milin, Solène Couespe, Hatem Necib, Françoise Kraeber-Bodéré, Catherine Ansquer, Thomas Carlier. Revisiting the Robustness of PET-Based Textural Features in the Context of Multi-Centric Trials. PLoS ONE (2016). inserm-01414301

Mahsa Eskian, Mirhojjat Khorasanizadeh, Francoise Kraeber-Bodere, Nima Rezaei. Radioimmunotherapy in non-Hodgkin lymphoma: Prediction and assessment of response. Critical Reviews in Oncology/Hematology (2016). inserm-01414377

Jérémie Ménager, Jean-Baptiste Gorin, Nolwenn Fichou, Sébastien Gouard, Alfred Morgenstern, Frank Bruchertseifer, François Davodeau, Françoise Kraeber-Bodéré, Michel Chérel, Joëlle Gaschet, Yannick Guilloux. Radio-immunothérapie alpha : Principes et intérêts en immunité antitumorale. Médecine/sciences (2016). inserm-01414777

Tahra Ayed, Julien Pilmé, David Tézé, Fadel Bassal, Jacques Barbet, Michel Chérel, Julie Champion, Gilles Montavon, Nicolas Galland, Rémi Maurice. 211 At-labeled agents for alpha-immunotherapy: On the in vivo stability of astatine-agent bonds. European Journal of Medicinal Chemistry (2016). inserm-01414904

Clotilde Dumars, Fanny Foubert, Yann Touchefeu, Nicolas Regenet, Hélène Senellart, Tamara Matysiak-Budnik, Marie-Françoise Heymann. Can PPH3 be helpful to assess the discordant grade in primary and metastatic enteropancreatic neuroendocrine tumors? Endocrine (2016). inserm-01415655

Caroline Bodet-Milin, Alain Faivre-Chauvet, Thomas Carlier, Aurore Rauscher, Mickael Bourgeois, Evelyne Cerato, Vincent Rohmer, Olivier Couturier, Delphine Drui, David Goldenberg, Robert Sharkey, Jacques Barbet, Francoise Kraeber-Bodere. Immuno-PET Using Anticarcinoembryonic Antigen Bispecific Antibody and 68Ga-Labeled Peptide in Metastatic Medullary Thyroid Carcinoma: Clinical Optimization of the Pretargeting Parameters in a First-in-Human Trial. Journal of Nuclear Medicine (2016). inserm-01415668

Caroline Rousseau, Thierry Rousseau, Cédric Mathieu, Jacques Lacoste, Eric Potiron, Geneviève Aillet, Pierre Nevoux, Georges Le Coguic, Loïc Campion, Françoise Kraeber-Bodéré. Laparoscopic sentinel lymph node dissection in prostate cancer patients: the additional value depends on preoperative data. European Journal of Nuclear Medicine and Molecular Imaging (2016). inserm-01415829

Jared Strydhorst, Thomas Carlier, Arnaud Dieudonné, Maurizio Conti, Irène Buvat. A gate evaluation of the sources of error in quantitative 90Y PET. Medical Physics (2016). inserm-01523817

Clément Bailly, Pierre-François Cléry, Alain Faivre-Chauvet, Mickael Bourgeois, François Guérard, Ferid Haddad, Jacques Barbet, Michel Chérel, Françoise Kraeber-Bodéré, Thomas Carlier, Caroline Bodet-Milin. Immuno-PET for Clinical Theranostic Approaches. International Journal of Molecular Sciences (2016). inserm-01636873

Françoise Kraeber-Bodéré, Jacques Barbet, Jean-François Chatal. Radioimmunotherapy: From Current Clinical Success to Future Industrial Breakthrough? Journal of Nuclear Medicine (2016). inserm-01809686

Françoise Kraeber-Bodere, Clément Bailly, Michel Chérel, Jean-François Chatal. ImmunoPET to help stratify patients for targeted therapies and to improve drug development. European Journal of Nuclear Medicine and Molecular Imaging (2016). inserm-01809742

T. Rousseau, J. Lacoste, E. Potiron, P. Nevoux, G. Le coguic, G. Aillet, L. Campion, Carole Rousseau. Atteinte ganglionnaire sentinelle et cancer de la prostate : quel impact sur la survie sans recidive ? À propos de 200 patients. Progrès en Urologie (2016). inserm-01809755

Laetitia Dorso, Edith Bigot-Corbel, Jérôme Abadie, Maya Diab, Sébastien Gouard, Frank Bruchertseifer, Alfred Morgenstern, Catherine Maurel, Michel Chérel, François Davodeau. Long-Term Toxicity of [213]Bi-Labelled BSA in Mice. PLoS ONE (2016). inserm-01809417

Nolwenn Dubois, Emmanuel Rio, Natacha Ripoche, Véronique Ferchaud-Roucher, Marie-Hélène Gaugler, Loic Campion, Michel Krempf, Christian Carrie, Marc Mahé, Xavier Mirabel, François Paris. Plasma ceramide, a real-time predictive marker of pulmonary and hepatic metastases response to stereotactic body radiation therapy combined with irinotecan. Radiotherapy and Oncology (2016). inserm-01333878

EQUIPE 14

Maëva Guillonneau, François Paris, Soizic Dutoit, Hala Estephan, Elise Bénéteau, Jacques Huot, Isabelle Corre. Oxidative stress disassembles the p38/NPM/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response. FASEB Journal (2016). inserm-01312779

Caroline Noblet, Sophie Chiavassa, F. Smekens, David Sarrut, V. Passal, J. Suhard, Albert Lisbona, François Paris, Grégory Delpon. Validation of fast Monte Carlo dose calculation in small animal radiotherapy with EBT3 radiochromic films. Physics in Medicine and Biology (2016). inserm-01321438

Marie-Claude Fadous-Khalifé, Nijez Aloulou, Majida Jalbout, Joseph Hadchity, Georges Aftimos, Francois Paris, Elie Hadchity. Krüppel-like factor 4: A new potential biomarker of lung cancer. Molecular and Clinical Oncology (2016). inserm-01321459

Viviane Silva, Florian Lafont, Houda Benhelli-Mokrani, Magali Le Breton, Philippe Hulin, Thomas Chabot, François Paris, Vehary Sakanyan, Fabrice Fleury. Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. International Journal of Molecular Sciences (2016). inserm-01321466

Baptiste Pichon, Loïc Campion, Grégory Delpon, François Thillays, Christian Carrie, Patrice Cellier, Pascal Pommier, Cécile Laude, Augustin Mervoyer, Hadji Hamidou, Marc-André Mahé, Stéphane Supiot. High-Dose Hypofractionated Radiation Therapy for Noncompressive Vertebral Metastases in Combination With Zoledronate: A Phase 1 Study. International Journal of Radiation Oncology (2016). inserm-01375551

EQUIPE 15

Tiphaine Douanne, Julie Gavard, Nicolas Bidère. The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling. Journal of Cell Science (2016). inserm-01311283

Kellen Cristine Tjioe, Denise Tostes Oliveira, Julie Gavard. Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma. Nutrition and Cancer (2016). inserm-01333887

Gwennan André-Grégoire, Julie Gavard. Spitting out the demons: Extracellular vesicles in glioblastoma. Cell Adhesion and Migration (2016). inserm-01382405

Tiphaine Douanne, Nicolas Bidère. HOIL1 cleavage by MALT1, the knives are out. Receptors & Clinical Investigation (2016). inserm-01385207

Héloïse Leclair, Gwennan André-Grégoire, Lucas Treps, Sandy Azzi, Nicolas Bidère, Julie Gavard. The E3 ubiquitin ligase MARCH3 controls the endothelial barrier. FEBS Letters (2016). inserm-01385212

Amel Hanini, Mohamed El Massoudi, Julie Gavard, Kamel Kacem, Souad Ammar, Ouajdi Souilem. Nanotoxicological study of polyol-made cobalt-zinc ferrite nanoparticles in rabbit. Environmental Toxicology and Pharmacology (2016). inserm-01385217

Elizabeth Harford-Wright, Nicolas Bidère, Julie Gavard. β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability. Oncotarget (2016). inserm-01385219

L Treps, S Edmond, E Harford-Wright, Em Galan-Moya, A Schmitt, A Azzi, A Citerne, N Bidère, D Ricard, J Gavard. Extracellular vesicle-transported Semaphorin 3A promotes vascular permeability in glioblastoma. Oncogene (2016). inserm-01406334

Hanini A, Lartigue L, Gavard J, Schmitt A, Kacem K, Wilhelm C, Gazeau F, Chau F, Ammar S. Thermosensitivity profile of malignant glioma U87-MG cells and human endothelial cells following g-Fe2O3 NPs internalization and magnetic field application. RSC Advances (2016). inserm-01406375

Hanini A, Lartigue L, Gavard J, Kacem K, Wilhelm C, Gazeau F, Chau F, Ammar S. Zinc substituted ferrite nanoparticles with Zn 0.9 Fe 2.1 O 4 formula used as heating agents for in vitro hyperthermia assay on glioma cells. Journal of Magnetism and Magnetic Materials (2016)

EQUIPE 16

Irina Panovska-Stavridis, Aleksandar Eftimov, Martin Ivanovski, Aleksandra Pivkova-Veljanovska, Lidija Cevreska, Sylvie Hermouet, Alexksandar Dimovski. Essential Thrombocythemia Associated With Germline JAK2 G571S Variant and Somatic CALR Type 1 Mutation. Clinical lymphoma, myeloma & leukemia (2016). inserm-01294720

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