Séminaire du département NOHMAD 08 juin
L’invité de ce séminaire sera Aurélien Sérandour, l’occasion de faire la connaissance de cet enseignant-chercheur a intégré récemment l’unité et qui officie également à l’Ecole Centrale.
Epigenomics: a tool to understand transcription regulation in cancer and human diseases
Scientists have studied human mutations of the coding genome for decades. This is in fact the tip of the iceberg of human disease-related mutations. More than 90% (maybe more) of the SNPs identified in GWAS studies are in fact located in non-coding regulatory elements (non-coding RNA, promoters, enhancers, insulators, splicing sites etc). I will show you how -omics methods allow us to better understand transcription regulation by non-coding regulatory elements in cancer and human diseases. In particular, epigenomics methods provide genome-wide mapping of transcription factors binding, histone and DNA modifications. Our current aim in Team 11 CRCINA (PI: S. Minvielle) is to map the active regulatory elements in clinical samples (normal plasma cells and multiple myeloma) so that we can identify key regulatory elements and key transcription factors implicated in the disease.